INTERACTION OF IMMUNE AND NERVOUS SYSTEMS WHEN USING PCL SCAFFOLDES IN MAXILOFACIAL SURGERY

An important parameter of scaffold matrices is biocompatibility. Biocompatibility assessment is carried out in several stages. At the first stage, its compatibility with in vitro cell cultures is determined. At the second in vivo stage, biocompatibility is assessed by examining histological preparations of tissue biopsies obtained from the area of implantation of scaffolds in experimental animals. Therefore, the following tasks are set: to determine the immunological compatibility of the blood cells of rabbits during the surgical introduction of scaffolds and to evaluate the nervous stress during operations. In our studies, the pcl scaffolds presented are polymeric biodegradable matrices that are polycaprolactone and polyhydroxybutyrate. Capsules consist of polypeptides and polysaccharides, the shell of which is coated with a layer of silicate nanoparticles.

scaffolds, matrices, biocompatibility, mesenchymal cells, implantance, cell cultivation, tissue engineering