NEUROIMMUNE PATTERN IN THE COMORBIDITY BETWEEN DEPRESSION AND ALCOHOL USE DISORDER

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Abstract

The aim of the study is to search for biomarkers of risk and prevention of the formation of alcohol dependence on the background of depression. Antibodies are evaluated for a number of neurotransmitters, the information content of which is confirmed by preliminary studies. Materials and methods. Autoantibodies to dopamine, norepinephrine, 5-hydroxytryptamine, glutamate, gamma-aminobutyric acid were determined by ELISA in 60 controls and patients with depression and alcohol use disorder (AUD). Results. The level of antibodies to all studied neurotransmitters decreases with depression, especially complicated by alcoholism. An exception is the level of antibodies to serotonin, which increases with AUD and depression combined with AUD. Conclusion. It is assumed that this type of reaction may be a biomarker of the risk of alcoholism in depression.

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T I Nevidimova

Mental Health Research Institute, Tomsk

T V Davydova

Institute of General Pathology and Pathophysiology, Moscow

L A Vetrile

Institute of General Pathology and Pathophysiology, Moscow

D N Savochkina

Mental Health Research Institute, Tomsk

I A Zakharova

Institute of General Pathology and Pathophysiology, Moscow

S A Galkin

Mental Health Research Institute, Tomsk

References

  1. Neupane SP. Neuroimmune Interface in the Comorbidity between Alcohol Use Disorder and Major Depression. Front Immunol. 2016;7:655. https://doi.org/10.3389/fimmu.2016.00655. eCollection.
  2. Ponizovskiy PA, Gofman AG. Depression in alcohol addicted patients. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(7):146-150. https://doi.org/10.17116/jnevro201511571146-150.
  3. Masterova E, Bokhan N, Nevidimova T, et al. Role of olfactory reactions, nociception, and immunoendocrine shifts in addictive disorders. American Journal on Addictions. 2017;26(6):640-648.
  4. Davydova TV, Vetrile LA, Nevidimova TI, et al. Dopamine, norepinephrine, glutamate antibodies in individual prevention of addiction. European Neuropsychopharmacology. 2017;27(Suppl 4):1078.

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Copyright (c) 2019 Nevidimova T.I., Davydova T.V., Vetrile L.A., Savochkina D.N., Zakharova I.A., Galkin S.A.

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