ENDURANCE OF RATS WITH DISBIOZ IN EMOTIONAL-PHYSICAL STRESS

Stress loads in sport lead to the development of functional disorders of various body systems, including the digestive system. The use of pharmacological preparations for correction of dysbiotic states is very often. The aim of this work was to study the physical endurance of rats with dysbiosis with decreased and increased intestinal circadian rhythm (ICR) under conditions of emotional-physical stress. Dysbiosis with a decreased ICR was caused by the administration of loperamide (LPR) 2 mg/2 ml of physiological saline daily subcutaneously for 6 days. Dysbiosis with increased ICR was caused by the addition of lactitol (LT) 10 g to 200 ml of drinking water daily for 6 days. To model emotional-physical stress, a forced swimming test until exhaustion (drowning) with a load of 7% of the animal’s body weight and a water temperature of 14 °C was used. In the control group, the life span of rats was 136 ± 8 s. LPR increased the physical endurance of rats by 1.94 times compared with control. LT also had a positive effect, increasing the duration of forced swimming in 1.44 times compared with the control. The combined use of LPR and LT did not lead to a change in animal’s endurance. Thus, both types of dysbiosis can be considered as a variant of endogenous stress, which plays the role of adaptogenic factor that increases resistance to a stronger emotional-physical stress, leading to the increase in physical endurance of animals.

stress, dysbiosis, loperamide, forced swimming, physical endurance