Email this article BRAIN CELLS REACTION IN A RESPONSE TO ANTIGEN INJECTION IN ANIMALS EXPOSED TO ACUTE PRENATAL STRESS
- Authors: Shakleina PS1, Novikova NS1
-
Affiliations:
- Institute of Experimental Medicine, Saint Petersburg
- Issue: Vol 19, No 1S (2019)
- Pages: 105-107
- Section: Articles
- Published: 15.12.2019
- URL: https://journals.eco-vector.com/MAJ/article/view/19350
- ID: 19350
Cite item
Open Access
Access granted
Abstract
Prenatal stress is one of the major cause of long-term disorders in behavioral and neuroimmunne processes. Emotional prenatal maternal stress (PRMS) performsin an offspring tendency to anxiety, depressive-like behavior and weakening memorizing skills. The study field was to determinate preproorexin gene expression of the maturity rats held in prenatal stress on the 19th day. The expression level was measured in two hours after intravenous LPS injection. qPCR shoved significant reduction in preproorexin gene expression in hypothalamus cells. This result corresponds with behavioral tests where animals exposed to stress during the late term of in utero development demonstrate less motion search activity which allovers to suspect a connection between prenatal stress and incidences of psycho-neuro-immunne relationships disorders.
Keywords
Full Text
About the authors
P S Shakleina
Institute of Experimental Medicine, Saint Petersburg
N S Novikova
Institute of Experimental Medicine, Saint Petersburg
References
- Шаклеина П.С. Влияние острого пренатального стресса на показатели стрессоустойчивости у взрослых самцов крыс породы Wistar // Материалы Международного молодежного научного форума «Ломоносов-2018» [Электронный ресурс]. - М.: МАКС Пресс, 2018, 1 электрон. опт. диск (DVD-ROM).
- Harris A, Seckl J. Glucocorticoids, prenatal stress and the programming of disease. HormBehav. 2011;59(3):279-89. https://doi.org/10.1016/j.yhbeh.2010.06.007.
- Arriagada-Solimano M, Luttecke-Anders A, Dagnino-Subiabre A, Iturra-Mena AM. Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats. J. Neuroendocrinol. 2018;30(7):e12609. https://doi.org/10.1111/jne.12609.
- Ji MJ, Zhang XY, Chen Z, et al. Orexin prevents depressive-like behavior by promoting stress resilience. Mol Psychiatry. 2019;24(2):282-293. https://doi.org/10.1038/s41380-018-0127-0.
- Perekrest SV, Shainidze KZ, Loskutov YuV, et al. Immunoreactivity of orexin-containing business in the level of expression of the preproorexin gene in these cells after administration of lipopolysaccharide. Neuroscience and Behavioral Physiology. 2013;43(2):256-260.
Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).