Email this article PRENATAL STRESS IN PROGRAMMING OF IMMUNE AND NEUROENDOCRINE SYSTEM DEVELOPMENT
- Authors: Zakharova LA1
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Affiliations:
- Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
- Issue: Vol 19, No 1S (2019)
- Pages: 124-126
- Section: Articles
- Published: 15.12.2019
- URL: https://journals.eco-vector.com/MAJ/article/view/19360
- ID: 19360
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Abstract
The analysis of published and original data demonstrates that prenatal stress induced by viral and bacterial infection, or changes in the physiological concentrations of neurohormones in early ontogeny can cause unfavorable impacts on the development of neuroendocrine and immune systems. In early pregnancy bacterial infection simulated by lipopolysaccharide in an experiment activates the maternal immune system, which enhances the synthesis of pro- and anti-inflammatory cytokines in both maternal and fetal organisms. Consequently, cytokines promote the secretion of a hormonal cascade in the hypothalamic-pituitary-adrenal system, thus eliciting the hormonal response to stress. Various stress factors during critical periods of neuroendocrine and immune system development modulate the epigenetic mechanisms controlling specific genes, which can affect the structure and function of these systems and increase the risk of various pathologies in the offspring.
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About the authors
L A Zakharova
Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
References
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).