STRUCTURAL AND FUNCTIONAL CHARACTERISTICS OF MICROGLIA IN THE POSTNATAL RAT STRIATUM

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Abstract

The aim of this study was to evaluate the morphological and functional characteristics of microglial cells in the rat striatum at different stages of postnatal development. Using immunocytochemical methods and fluorescent microscopy, brain sections were analysed at each of the following postnatal ages: day 7 (n = 4), day 14 (n = 3), 4 to 6 months (n = 3). Different morphological and functional types of microglial cells were identified and characterized in details. It was noted that microglia activated during normal brain development do not contain vimentin, which is characteristic of stroke-activated microglia.

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About the authors

M V Antipova

Saint Petersburg State University, Saint Petersburg; Institute of Experimental Medicine, Saint Petersburg

V V Guselnikova

Institute of Experimental Medicine, Saint Petersburg

D E Korzhevskii

Institute of Experimental Medicine, Saint Petersburg

References

  1. Wolf SA, Boddeke HW, Kettenmann H. Microglia in Physiology and Disease. Annual Review of Physio¬logy. 2017;79(1):619-643.
  2. Wilhelmsson U, Andersson D, de Pablo Y, et al. Injury leads to the appearance of cells with characteristics of both microglia and astrocytes in mouse and human brain. Cereb Cortex. 2017;6:3360-3377.

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Copyright (c) 2019 Antipova M.V., Guselnikova V.V., Korzhevskii D.E.

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