FEATURES OF MAST CELL RESPONSE AND VEGF EXPRESSION IN THE SKIN DEPENDING ON THE POWER OF LASER EXPOSURE

The aim of the work was to study the dynamics of morphofunctional reactions of mast cells and VEGF expression in the skin of rats after infrared 970 nm laser exposure with 1.0, 3.0 and 5.0 W power. Removal of animals from the experiment was carried out 1 hour and 1 day after irradiation. The significant increase in mast cells degranulation index in the abdominal skin was noted 1 hour after irradiation with the increase in power from 1 to 5 W and as compared with the control. The study showed the VEGF expression increase in the dermis 1 hour after 1 W power irradiation and in the subepidermal, dermal and hypodermal layers 1 day after the irradiation compared with the control. When using 3 W and 5 W laser irradiation, an increase in VEGF expression was observed in all layers of the abdominal skin both for 1 hour and for 1 day in comparison with the control. Since mast cell degranulation and VEGF expression are higher after 3 and 5 W infrared laser irradiation, these parameters are preferable for stimulating microcirculation in the skin.

mast cells, growth factor, laser, skin