THE EFFECT OF KE PEPTIDE ON THE TELOMERE LENGTH OF PHA-STIMULATED HUMAN LYMPHOCYTES

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Abstract

The goal of the research is to study the effect of KE peptide on telomere length of PHA-stimulated blood lymphocytes of young and middle-aged men. 11 blood lymphocyte samples were enrolled in the analysis. Relative telomere length was measured using fluorescence in situ hybridization with DNA-probes specific to telomere sequences of human chromosomes. 5 cases of significant telomere length alteration were registered. These changes were more frequent registered in middle-aged people: 4 invents cases versus 1. KE peptide increased telomere length in blood lymphocytes of middle-aged people if it was basically low and, vice versa, decreased the basically high telomere length.

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About the authors

V Kh Khavinson

Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg; Pavlov Institute of Physiology of RAS, Saint Petersburg; North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg

N S Linkova

Saint Petersburg Institute of Bioregulation and Gerontology, Saint Petersburg; Academy of Postgraduate Education under FSBU FSCC of FMBA of Russia, Moscow

A A Pendina

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg

O A Efimova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg

A S Koltsova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg; Saint Petersburg State University, Saint Petersburg

M I Krapivin

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg; Saint Petersburg State University, Saint Petersburg

A V Tikhonov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg

L I Petrova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg

A V Petrovskaia-Kaminskaia

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg; Saint Petersburg State University, Saint Petersburg

V S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg; Saint Petersburg State University, Saint Petersburg

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Copyright (c) 2019 Khavinson V.K., Linkova N.S., Pendina A.A., Efimova O.A., Koltsova A.S., Krapivin M.I., Tikhonov A.V., Petrova L.I., Petrovskaia-Kaminskaia A.V., Baranov V.S.

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