PROBABLE ANALGESIC EFFECT OF SYNTHETIC TETRAPEPTIDE

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Abstract

The aim of the study was to elucidate the molecular mechanisms of modulation of the NaV1.8 channels with a synthetic tetrapeptide (Ac-RERR-NH2). Our data suggest that this substance specifically modulates the activation gating device of these channels, which are responsible for coding of pain signals. This agent (0.1 nM) has a neurite-stimulating effect, which indicates its possible physiological regeneration effect on the nervous tissue. The results obtained allow us to conclude that the agent under study can claim to be the drug substance of a safe and effective analgesic.

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V B Plakhova

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

V A Penniyaynen

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

I V Rogachevskii

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

S A Podzorova

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

E A Merculova

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

B V Krylov

Pavlov Institute of Physiology of the Russian Academy of Sciences, Saint Petersburg

References

  1. Plakhova VB, Rogachevskii IV, Shchegolev BF, et al. Defensin NP-4 decreases voltage-sensitivity of slow sodium channels in sensory neuron. Sensornye Sistemy. 2005;19(2):110-116. (In Russ.).
  2. Krylov, BV, Rogachevskii IV, Shelykh TN, Plakhova VB. New non-opioid analgesics: understanding molecular mechanisms on the basis of patch-clamp and quantum-chemical studies. Frontiers in pain sci. Sharjah: Bentham Sci. Publ. 2017;1:203.
  3. Penniyaynen VA, Plakhova VB, Rogachevskii IV, Krylov BV. Src kinase is involved in comenic acid-triggered signaling pathways in sensory neurons. Activitas nerv. super. Rediviva. 2018;60(1):19-27.

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Copyright (c) 2019 Plakhova V.B., Penniyaynen V.A., Rogachevskii I.V., Podzorova S.A., Merculova E.A., Krylov B.V.

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