Gap junction protein connexin-43 and its distribution in different tissues

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Abstract

Connexins is the family of proteins which in vertebrates form gap junctions – intercellular contacts allowing the passage of small molecules between cells. Connexin-43 is the most abundant member of connexin family in human. Its cellular functions are diverse, and its localization in the human body is the most wide across all connexins. Most intensive research is devoted to the investigation of соnnexin-43 role in intercellular communication and its functional features in the vital organs — heart and brain. Due to high abundance in different tissues, at the moment there is the large amount of various experimental data, which are hard to assemble into global picture. This work aims to present generalized information about the distribution and functions of соnnexin-43 in various tissues and further prospects for studying this protein using the currently available literature data.

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About the authors

Mikhail S. Filippov

Institute of Experimental Medicine

Email: msfilippov@mail.ru
SPIN-code: 7789-7219

Research Laboratory Assistant, Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

Russian Federation, Saint Petersburg

Dmitrii E. Korzhevskii

Institute of Experimental Medicine

Author for correspondence.
Email: DEK2@yandex.ru
ORCID iD: 0000-0002-2456-8165
SPIN-code: 3252-3029

MD, Dr. Sci. (Med.), Professor of the Russian Academy of Sciences, Head of the Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

Russian Federation, Saint Petersburg

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2. Figure. Detection of intercalated discs in human heart cardiomyocytes using the reaction of Cx43 (specimen from the archives of the Department of General and Special Morphology of the Institute of Experimental Medicine). Cardiomyocyte nuclei are stained with SYTOX Green dye, Cx43 is detected by antibodies visualized with Cy3 fluorochrome

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