Effects prenatal exposure to peat smoke on the emotional behavior of rat offspring and its correction with fabomotizole
- Authors: Ivashova D.M.1, Litvinova S.A.1, Voronina T.A.1, Tsorin I.B.1
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Affiliations:
- Zakusov Research Institute of Pharmacology
- Issue: Vol 21, No 1 (2021)
- Pages: 47-58
- Section: Original research
- Published: 10.06.2021
- URL: https://journals.eco-vector.com/MAJ/article/view/60528
- DOI: https://doi.org/10.17816/MAJ60528
- ID: 60528
Cite item
Abstract
Relevance. Long-term smoke from forest fires cause a wide range of health disorders, including somatic state, emotional status, and cognitive functions. The question of the consequences of exposure to combustion products of peat and wood during pregnancy for offspring remains open.
Intention. The goal is to explore the disorders (anxiety, reflex behavior, aggression, etc.) that occur in the offspring of rats exposed to peat smoke in the early and late postnatal periods and the effect of fabomotizole on these disorders.
Methodology. The research was conducted on the offspring of rats of both sexes from females forcibly exposed to peat smoke (1-20 days). The effect of peat smoke on rats and the protective effect of fabomotizole (1 and 10 mg / kg / 20 days of gestation) were studied in the early (5 days) and late (60-80 days) postnatal periods. The formation of the sensory-motor reflex, anxiety, aggression, and motor activity were assessed.
Results and discussion. Exposure to peat smoke of pregnant females (from 1-20 days of gestation) causes a perturb in the formation of a sensory-motor reflex in the early postnatal period ( 5 days), a decrease in the level of natural adaptive reactions and intraspecific aggression, as well as an increase in locomotor activity in mature animals (60-80 days). Fabomotizole, when administered prenatally (1-20 days of gestation) at doses of 1 and 10 mg / kg, corrected the formation of a conditioned sensory-motor reflex in male and female rat pups, data of the emotional status and motor activity of sexually mature animals.
Conclusion. The protective effect of fabomotizole on the offspring of rats prenatally exposed to peat smoke from the toxic effects of peat combustion products was revealed. Fabomotizole returns the studied behavioral reactions, disturbed by peat, to the level of the physiological norm, which confirms the previously established cyto- and neuroprotective properties of the drug.
Keywords
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About the authors
Dinara M. Ivashova
Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: pharmacevt07@mail.ru
Researcher of the Laboratory of Psychopharmacology
Russian Federation, MoscowSvetlana A. Litvinova
Zakusov Research Institute of Pharmacology
Email: sa_litvinova@mail.ru
MD, PhD (Biology), Leading Scientific worker of the Laboratory of Psychopharmacology
Russian Federation, MoscowTatiana A. Voronina
Zakusov Research Institute of Pharmacology
Email: voroninata38@gmail.com
MD, PhD, DSc (Medicine), Professor, Head of the Laboratory of Psychopharmacology
Russian Federation, MoscowIosif B. Tsorin
Zakusov Research Institute of Pharmacology
Email: tsorinib@yandex.ru
MD, PhD, DSc (Biology), Leading Scientific worker of the Laboratory of Pharmacological
Russian Federation, MoscowReferences
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