Email this article ANXIETY IN RATS EXPOSED TO VITAL STRESS IN ASSOCIATION WITH DELAYED TRAUMA REMINDER
- Authors: Vorobeva A.S.1, Timusheva M.V.1, Absalyamova M.T.1, Beznin G.V.1, Apraksina N.K.1, Tsikunov S.G.1
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Affiliations:
- Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
- Section: Original research
- Published: 06.07.2024
- URL: https://journals.eco-vector.com/MAJ/article/view/630042
- DOI: https://doi.org/10.17816/MAJ630042
- ID: 630042
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Abstract
Background. Modeling intrusive memories of psychologically traumatic event in post-traumatic stress disorder (PTSD) and assessing the development of mental disorders in the long-term period is relevant in order to understand the mechanisms of vital stress caused. Pathological anxiety may reflect the experienced feeling of fear and helplessness and intrusive traumatic memories in PTSD.
Aim. The purpose of the study was to assess the level of anxiety and exploratory activity of male rats in the Elevated Plus Maze (EPM) test after experiencing vital stress in association with twice repeated trauma reminders in a delayed period.
Materials and methods. The study was performed on mature male Wistar rats weighing 300–350 g (n = 34). Mental trauma was modeled by the circumstances of experiencing the situation of partner’s death from the action of a predator and the threat to their own life when placing rats in a terrarium with a tiger python. In rats, the behavior in the EPM test was analyzed two months after an exposure to stress.
Results. In the delayed period after vital stress, the EPM test showed an increase in anxiety and a decrease in exploratory activity of male rats. When placed twice in a traumatic environment, male rats with previously received psychogenic trauma maintained an increased level of anxiety and suppression of exploratory activity in the long-term period.
Conclusion. Two months after vital stress, male rats show increased anxiety and reduced exploratory activity. The traumatic event reminder leads to worsening of behavioral disorders caused by psychogenic trauma, indicating a stable, long-lasting development of PTSD.
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About the authors
Arina S. Vorobeva
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Author for correspondence.
Email: vorobevarin@mail.ru
ORCID iD: 0009-0005-5743-9983
Laboratory assistant-researcher at the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.Maria V. Timusheva
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Email: mariatimusheva@mail.ru
ORCID iD: 0009-0007-9176-9868
Laboratory assistant-researcher at the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.Margarita T. Absalyamova
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Email: margarita-abs@yandex.ru
ORCID iD: 0000-0002-1326-7383
SPIN-code: 1988-6781
Laboratory assistant-researcher at the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.Gleb V. Beznin
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Email: beznin.gv@iemspb.ru
ORCID iD: 0000-0001-5730-4265
SPIN-code: 7796-1107
Researcher at the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.Natalia K. Apraksina
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Email: natalapraksina@mail.ru
ORCID iD: 0000-0001-5285-6589
SPIN-code: 2450-9282
Senior researcher at the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.Sergey G. Tsikunov
Federal State Budgetary Scientific Institution “Institute of Experimental Medicine”.
Email: secikunov@yandex.ru
ORCID iD: 0000-0002-7097-1940
SPIN-code: 7771-1940
Head of the laboratory of psychophysiology of emotions of the I.P. Pavlov physiological department of the FSBSI “IEM”, Doctor of Medical Sciences, professor
Russian Federation, 197022, Russia, St. Petersburg, st. Academician Pavlova, 12.References
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