EPIGENETIC CHANGES IN POST-TRAUMATIC STRESS DISORDER: POSSIBILITIES AND LIMITATIONS OF EPIGENETIC THERAPY



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Abstract

The review describes epigenetic mechanisms that may contribute to individual differences in resistance and risk of developing post-traumatic stress disorder. The review provides data on the potential use of epigenetic modifications as biomarkers of traumatic stress and factors responsible for the inheritance by offspring of the negative consequences of psychogenic trauma suffered by their parents. The possibilities and limitations of epigenetic therapy of post-traumatic and stress-related disorders are discussed.

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About the authors

Irina Olegovna Suchkova

FSBSI «Institute of Experimental Medicine»

Author for correspondence.
Email: irsuchkova@mail.ru
ORCID iD: 0000-0003-2127-0459
SPIN-code: 4155-7314
Scopus Author ID: 6602838276
ResearcherId: H-4484-2014

PhD, Cand. Sci. (Biol.), Senior Research Associate, Laboratory of Molecular cytogenetics of mammalian development, Department of Molecular genetics

Russian Federation, 197022, Saint-Petersburg, Acad. Pavlov str., 12

Eugene L'vovich Patkin

FSBSI "Institute of Experimental Medicine"

Email: elp44@mail.ru
ORCID iD: 0000-0002-6292-4167
SPIN-code: 4929-4630
Scopus Author ID: 7003713993
ResearcherId: J-7779-2013

MD, Dr. Sci. (Biol.), Professor, Head of Laboratory of Molecular Cytogenetics of Mammalian Development, Department of Molecular Genetics

Russian Federation, 197022, St. Petersburg, Acad. Pavlova str., 12

Sergey Georgievich Tsikunov

FSBSI "Institute of Experimental Medicine"

Email: secikunov@yandex.ru
ORCID iD: 0000-0002-7097-1940
SPIN-code: 7771-1940
Scopus Author ID: 6506948997
ResearcherId: E-6273-2014

MD, Dr. Sci. (Med.), Professor, Head of the Laboratory of the Psychophysiology of Emotions of Physiological Department named I.P. Pavlov

Russian Federation, 197022, Russia, Saint Petersburg, Acad. Pavlov str.,12

Henrikh Aleksandrovich Sofronov

Military Medical Academy named after. C.M. Kirov of the Ministry of Defense of the Russian Federation; FSBSI "Institute of Experimental Medicine"

Email: gasofronov@mail.ru
ORCID iD: 0000-0002-8587-1328
SPIN-code: 7334-4881
Scopus Author ID: 7003953555
ResearcherId: G-4791-2015

MD, Dr. Sci. (Med.), Professor, Academician of RAS, Head of the Laboratory of Medicinal and Environmental Toxicology of the Research Department (medical and biological research) of the Research Center; Scientific director of Federal State Budget Scientific Institution «Institute of Experimental Medicine»

Russian Federation, 194044, St. Petersburg, Acad. Lebedeva str., 6; 197022, St. Petersburg, Acad. Pavlov str., 12

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