HABITUATION OF PHASIC DOPAMINE RELEASE: HYPOTHESIS AND EVIDENCE



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Abstract

This article describes a phenomenon of gradual reduction in evoked phasic extracellular dopamine level elevations (PDE) during repeated stimulation of dopaminergic brain structures of experimental animals. By identifying characteristic signs, the hypothesis is justified that the decrease in PDE is due to habituation - one of the forms of non-associative learning. The material for identifying the signs of habituation is the results of two new experiments, previously published studies, and literature data. In the experiments, the induction of PDE was carried out by electrical stimulation, and their registration was carried out by fast-scan cyclic voltammetry. Experiment 1, performed on anesthetized rats, confirmed the existence of the phenomenon of gradual reduction in PDE in the nucleus accumbens core. The results of experiment 2, conducted on the rat brain slices, made it possible to localize the physiological mechanism of PDE habituation in the area of dopaminergic nerve endings. Based on the kinetic analysis of PDE, we can conclude, that the habituation is caused by the decrease in the dopamine release, not by the increase in its reuptake.

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About the authors

Valery N. Mukhin

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"

Author for correspondence.
Email: valery.mukhin@gmail.com
ORCID iD: 0000-0003-0999-6847
SPIN-code: 3655-9126
Scopus Author ID: 57204253686
ResearcherId: E-6735-2014

Senior scientific researcher, Pavlov Department of Physiology

Russian Federation, Acad. Pavlov str., 12, St. Petersburg, 197376, Russia

Ivan R. Borovets

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"

Email: o.1330medach@gmail.com
ORCID iD: 0000-0003-3737-1537
Scopus Author ID: 57220181570
ResearcherId: ADQ-1493-2022

Junior Researcher, Ivan P. Pavlov Department of Physiology

Russian Federation, Acad. Pavlov str., 12, St. Petersburg, 197376, Russia

Alexandr Y. Terekhov

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"

Email: hazker735@gmail.com
ORCID iD: 0000-0001-7007-2067
Scopus Author ID: 57216356365
ResearcherId: W-3040-2018

postgraduate student, Ivan P. Pavlov Department of Physiology

Russian Federation, Acad. Pavlov str., 12, St. Petersburg, 197376, Russia

Victor M. Klimenko

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"

Email: klimenko_victor@mail.ru
ORCID iD: 0000-0001-9701-4537
SPIN-code: 8709-5642
Scopus Author ID: 14066179000
ResearcherId: A-4703-2016

professor, Leading Researcher of Ivan P. Pavlov Department of Physiology

Russian Federation, Acad. Pavlov str., 12, St. Petersburg, 197376, Russia

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