Применение наночастиц серебра в медицине: плюсы и минусы; преимущества композитов наночастиц серебра с органическими антибактериальными субстанциями и биосовместимыми полимерами



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Развитие резистентности бактерий к применяемым в клинической практике препаратам является серьезной проблемой современной медицины. Наночастицы в настоящее время широко используются в различных отрослях промышленности, а также в медицине. Антибактериальный потенциал наночастиц серебра обширен и распространяется на грамотрицательные и грамположительные бактерии, включая мультирезистентные штаммы, в том числе в составе бактериальных биопленок. Установлено, что наночастицы серебра имеют множественные мишени антимиробного действия, вследствие чего развитие микробной резистентности к ним затруднено. Кроме того, для серебра описаны другие виды биологической активности: ранозаживляющая, противовоспалительная, противоопухолевая. Однако, несмотря на несомненные достоинства этих наноматериалов, до сих пор остаются и проблемы с их применением в медицине, связанные с некоторыми нежелательным влиянием на живые объекты. Столь разнообразные биологические свойства, а также потенциальная токсичность наночастиц серебра определяются размером и формой наночастиц, способом их синтеза и видом стабилизирующего агента. В данном обзоре приводится информация по спобсобам модификации наночастиц серебра антибактериальными соединениями, такими как антибиотики, антимикробные пептиды, которые демонстрируют синергические и аддитивные воздействия против патогенных бактерий при использовании в комбинации с наночастицами, а при создании комплексов повышают антимикробную активность и обеспечивают стабильность наночастиц. Поэтому композиты наночастиц серебра с органическими антибактериальными препаратами и биосовместимыми полимерами могут рассматриваться как перспективная основа для создания новых эффективных антибактериальных препаратов, лишенных нежелательных свойств.

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Елизавета Васильевна Владимирова

ФГБНУ "Институт экспериментальной медицины"

Email: vladymyrovaliza18@mail.ru
ORCID iD: 0000-0002-6576-9844

Ольга Валерьевна Шамова

Институт экспериментальной медицины, Санкт-Петербург

Автор, ответственный за переписку.
Email: oshamova@yandex.ru
ORCID iD: 0000-0002-5168-2801

Доцент, доктор биологических наук, член-корреспондент РАН, заведующий отделом общей патологии и патологической физиологии

Россия

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Growing bacterial resistance to conventional antibiotics is a serious problem of contemporary medicine. Nanoparticles are now widely used in various branches of industry and in medicine. The antibacterial potential of silver nanoparticles is extensive and spreads to Gram-negative and Gram-positive bacteria, including multidrug-resistant strains, and bacteria in biofilms. Silver nanoparticles have multiple targets of antibacterial action therefore the microbial resistance to them is hardly developing.  In addition, other types of biological activity have been described for silver: wound-healing, anti-inflammatory, anti-tumor. Such diverse biological properties, as well as potential toxicity of silver nanoparticles, are determined by their size and shape, the method of nanpoparticles synthesis and the type of stabilizing agent. However, despite the undoubted advantages of these nanomaterials, there are still problems with their application in medicine due to some undesirable effects on living objects. This review provides information on methods for modifying silver nanoparticles with antibacterial agents, such as antibiotics, antimicrobial peptides, which demonstrate a synergistic and additive effects against pathogenic bacteria, taken in combinations with nanoparticles as well as increase their antimicrobial activity and ensure stability when used as complexes with these nanomaterials. Thus, composites of silver nanoparticles with organic biocompatible preparations can be considering as a promising base for creating new effective antimicrobial drugs devoid of undesirable properties.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 


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