Noninvasive diagnostic of external genital endometriosis based on the determination of cytokines controlling angiogenesis (literature review)

External genital endometriosis is a chronic, inflammatory desease affecting 10% of women of reproductive age, characterized by neoangiogenesis in endometriotic implants, which is controlled by a variety of factors. Recently, a wealth of information, have been devoted on study of the pathogenetic role of cytokines and other factors of peripheral blood and peritoneal fluid in endometriosis. Despite, a highly sensitive and highly specific marker for noninvasive diagnostic of endometriosis has not yet been identified. Color doppler imaging (CDI), being one of the non-invasive research methods of the vascular bed, is increasingly used to determine the type of vascularization in malignant tumors. Despite endometriosis is considered a benign lesion according to the histological picture, it still has signs of invasiveness and distant metastasis, with similar patterns of formation of the vascular bed feeding endometriotic implants. The purpose of this review was to systematize the literature data on the content and pathogenetic role of cytokines and factors controlling angiogenesis in peritoneal fluid and in the peripheral blood in women with endometriosis and also correlation with CDI parameters in cases of genital endometriosis.