THE EFFECT OF HALOPERIDOL ON THE CENTRAL NERVOUS SYSTEM OF MICE WHEN ADMINISTERED INTRANASALLY

Aim. To compare the pharmacological activity of the antipsychotic haloperidol with intranasal and intraperitoneal administration.
Materials and methods. The study involved 125 outbred male mice. The animals received haloperidol intranasally and intraperitoneally at doses of 0.1, 0.5 and 1 μg. Animal behavior was studied using the Open Field, Lecturer's Pose, and Pole Test tests after 30, 60, and 120 minutes. Results. This study demonstrated the effect of intranasal and intraperitoneal haloperidol administration on mouse behavior. Haloperidol administered intranasally and intraperitoneally caused a reliable change in the Pole Test (increase in the turnaround time and descent time), Open Field (decrease in horizontal and vertical motor activity of the minks studied), and Lecturer's Pose (increase in the time spent in the lecturer's pose) at a dose of 1 mg/kg.
Conclusion. Intranasal drug administration, along with other parenteral methods, can be considered an effective way to deliver drugs in diseases of the central nervous system. In preclinical studies, intranasal haloperidol administration can be used to model catalepsy in animals.