Recombinant vaccines against group B streptococci as mean of specific disease prevention

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Abstract

Prevention of the infections caused by Group B streptococci (GBS) is an important medical problem. At present research involved in construction of GBS vaccine is carried out in many different laboratories. This article contains the data devoted to the construction of recombinant vaccine against GBS based on the usage of immunogenic peptides corresponding to the GBS surface proteins. Peptides corresponding to the fragment of protein Bac and protein ScaAB provides protection of experimental animals against GBS This fact allows considering these peptides as promising vaccine candidates.

About the authors

A. Suvorov

Research Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

K. Grabovskaya

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

G. Leontieva

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

L. Meringova

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. Vorobieva

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

A. Totolian

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, St. Petersburg

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