Evaluation of the role of same detoxycation genes for preclinical diagnosis of bronchial asthma and its primary prevention

Goal: Development of consistent organizational system of medical care for women of childbearing age with diagnosed bronchial asthma and approaches for allergic pathology primary prophylactics in their kids

Materials and Methods: Examination and treatment of 250 pregnants with diagnosed BA by pulmonologist and obstetrician. Examination and treatment of 185 kids by neonatologist and pediatrician with conduct of all the procedures on primary prophylactics of allergic diseases. All the mothers passed spirometry and body plethysmography and genetic study GSTT1, GSTM1 with the use of PCR. Obstetrician performed clinical observation, dynamic ultrasound assessment, Doppler scan and haemostasis laboratory assessment. Genetics study had been enrolled for all kids.

Results: All BA pregnants were referred to pulmonologist. Individual curation plan and the system or preventive actions were developed according to the results of comprehensive examination. Complex examination and treatment allow to decrease the frequency of gestosis development, chronic placental insufficiency, potential miscarriage, threatened preterm labor, premature delivery. System of primary prophylaxis of allergic diseases in children, provided during their mother’s pregnancy, led to the elimination of different types of allergens. Estimation of genetic susceptibility to allergic diseases is performed for newborns are undergo, mothers are receiving recommendations on tolerance development and allergens dissociation. Kids are registered with neonatologist and from the age of 1 are switched to pediatrician. Genotypes GSTM1 0/0 and GSTT1 0/0 are risk factors of development of BA.