Email this article Genetic methods in diagnostics and prognosis of development of autoimmune endocrine diseases
- Authors: Bubnova L.N.1,2,3, Glazanova T.V.1,2,3, Potin V.V.1,2,3, Simbirtsev S.A.1,2,3
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Affiliations:
- Russian Research Institute of Hematology and Transfusiology
- Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences
- Medical Academy of Postgraduate Studies
- Issue: Vol 6, No 1 (2006)
- Pages: 83-89
- Section: Research in clinical medicine
- Published: 13.10.2025
- URL: https://journals.eco-vector.com/MAJ/article/view/692978
- ID: 692978
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Abstract
The data are presented about immunogenetic associations of type 1 Diabetes Mellitus (DM type 1), Graves’ disease (GD) and Hashimoto thyroiditis (HT) with HLA II class genes. Molecular HLA II class typing was performed using polymerase chain reaction method in 65 patients with DM type 1,67 - with GD and 74 -with HT. We have shown the common immunogenetic basis for these organospecific autoimmune endocrine diseases, a predisposing specificity is HLA-DRB1*03 and its interlocus association with DQB1*0201, DQA1*0501. Also, in patients with DM type 1 the following specificities occur more frequently than in healthy population control: DRB1*04, DQB1*0201, DQB1*0302, DQA1*0301. In the group of patients with GD with endocrine ophthalmopathy HLA-DRB1*03 frequency was even higher than in the whole GD group (with and without endocrine ophthalmopathy). Also we have established a range of protective HLA-specificities. The obtained data are of importance for early diagnostics, prognosis of course and development of such widely spread autoimmune endocrine diseases, as GD and HT and, especially DM type 1.
About the authors
L. N. Bubnova
Russian Research Institute of Hematology and Transfusiology; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences; Medical Academy of Postgraduate Studies
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
T. V. Glazanova
Russian Research Institute of Hematology and Transfusiology; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences; Medical Academy of Postgraduate Studies
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
V. V. Potin
Russian Research Institute of Hematology and Transfusiology; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences; Medical Academy of Postgraduate Studies
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg; St. Petersburg; St. Petersburg
S. A. Simbirtsev
Russian Research Institute of Hematology and Transfusiology; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences; Medical Academy of Postgraduate Studies
Email: shabanov@mail.rcom.ru
член-корреспондент
Russian Federation, St. Petersburg; St. Petersburg; St. PetersburgReferences
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).