Genetic and epigenetic mechanisms in the realisation of hereditary information

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Abstract

Phenotypic variability of organisms is not solely conditioned by the nucleotide sequence of nuclear genome, but also by traits encoded in mitochondrial DNA and by epigenetic factors. An example of nuclear genome-independent phenotypic variations among close relatives are alterations of energy metabolism transmitted along maternal lineage. Manifestations of epigenetic regulation of nuclear genes' activity are parental imprinting and X chromosome inactivation. Such regulation includes variations in DNA methylation and/or introduction satellite DNA into the regions of nuclear genome under regulation.

About the authors

V. B. Vasiliev

Research Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. L. Patkin

Research Institute of Experimental Medicine of the RAMS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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