The role of infection in formation of human endocrine disorders

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article offers contemporary data concerning the role of infection in pathogenesis of the most common human endo­crine diseases. The problem of affinity of different bacteria and viruses to endocrine organs as the pancreatic islets, thyroid gland, adrenals and testicles was analyzed. The main pathogenic mechanisms of endocrine disorders and functional details of separate endocrine glands lesion in infectious diseases were shown. The article represents the basic information about pecu­liarities of endocrine disorders in HIV-infection and chronic viral hepatitis type C.

About the authors

Y. V. Lobzin

Military Medical Academy

Author for correspondence.
Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, St. Petersburg

Y. S. Khalimov

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

References

  1. Болезни щитовидной железы / Под ред. Л. И. Бравермана. М.: Медицина, 2000.
  2. Дедов И. И., Шестакова М. В. Сахарный диабет: Рук-во для врачей. М.: Медицина, 2003.
  3. Дедов И. И., Мельниченко Г. А., Фадеев В. В. Эндокринология. М.: Медицина, 2000.
  4. Йен С. С. К., Джаффе Р. Б. Репродуктивная эндокринология. М.: Медицина, 1998.
  5. Мельниченко Г. А., Фадеев В. В., Бузиашвили И. И. Этиологические аспекты первичной хронической надпочечниковой недостаточности // Пробл. эндокринол. 1998. Т. 44. № 4. С. 46-55.
  6. Adamopoulos D. A., Lawrence D. М., Vassilopoulos Р. et al. Pituitary-testicular interrelationships in mumps orchitis and other viral infections // Br. Med. J. 1978. Vol. l.P. 1177-1180.
  7. Aiman J., Brenner P. F., MacDonald P. C. Androgen and estrogen production in elderly men with gynecomastia and testicular atrophy after mumps orchitis // J. Clin. Endocrinol. Metab. 1980. Vol. 50. P. 380-386.
  8. AIDosary A. A., Ramji A. S., Elliott T. G. et al. Post-liver transplantation diabetes mellitus: an association with hepatitis C // Liver transp. 2002. Vol. 8. P. 356-361.
  9. Annane D., Bellissant E., Bollaert P. E. Thehypothalamopituitary axis in septic shock // Br. J. Intens. Care. 1996. Vol. 6. P. 260-268.
  10. Antonelli A., Ferri C., Fallahi P. etal. Thyroid cancer in HCV-related chronic hepatitis patients: a casecontrol study // Thyroid. 2007. Vol. 17. № 5. p. 447-451.
  11. Antonelli A., Ferri C., Fallahi P. et al. Thyroid disorders in chronic hepatitis C virus infection // Thyroid. 2006. Vol. 16. № 6. P. 563-572.
  12. Arlt W., Allolio B. Adrenal insufficiency // Lancet. 2003. Vol. 361. P. 1881-1893.
  13. Basilio-De-Oliveira C. A. Infectious and neoplastic disorders of the thyroid in AIDS patients: an autopsy study // Braz. J. Infect. Dis. 2000. Vol. 4(2). P. 67-75.
  14. Beard С. M., Benson R. C., Kelalis P. P. et al. The incidence and outcome of mumps orchitis in Rochester, Minnesota, 1935 to 1974 // Mayo Clin. Proc. 1977. Vol. 52. P. 3-7.
  15. Beishuizen A., Thijs L. G„ Vermes I. Patterns of corticosteroidbinding globulin and the free cortisol index during septic shock and multitrauma // Intensive Care Med.2001. Vol.27. P. 15 84-1591.
  16. Bhasin S., Storer T. ИС, Javanbakht M. et al. Testosterone replacement and resistance exercise in HlV-infected men with weight loss and low testosterone levels // JAMA. 2000. Vol. 283. P. 763-770.
  17. Buzelin F, Karam G„ Moreau A. Testicular tumor and the acquired immunodeficiency syndrome // Eur. Urol. 1994. Vol. 26. P. 71-76.
  18. Camma C., Bruno S., Di Marco V. et al. Insulin resistance is associated with steatosis in nondiabetic patients with genotype 1 chronic hepatitis C //Hepatol¬ogy. 2006. Vol. 43. P. 64-71.
  19. Castera L., Hezode C., Roudot-Thoraval F Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis and paired liver biopsies // Gut. 2003. Vol. 52. P. 288 -292.
  20. Chesnokova V., Melmed S. Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gpl30 Signaling Molecules // Endocri¬nology. 2002. Vol. 143. № 5. P. 1571-1574.
  21. Corapcioglu D., Топуикик И, Kiyan М. etal. Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies // Thyroid. 2002. Vol. 12. P. 613-617.
  22. Croxson T. S., Chapman W. E., Miller L. K. Changes in the hypothalamic-pituitary-gonadal axis in human immunodeficiency virus-infected homosexual men H J. Clin. Endocrinol. Metab. 1989. Vol. 68. P. 317-321.
  23. D'Souza R, Sabin A., Foster G. R. Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy // Am. J. Gastroenterol. 2005. Vol. 100. P. 1509-1515.
  24. De Paepe M. E., Guerri C., Waxman M. Opportunistic infections of the testis in the acquired immunodeficiency syndrome // Mt. Sinai J. Med. 1990. Vol. 57. P. 25-29.
  25. Dejucq N., Jegou B. Viruses in the mammalian male genital tract and their effects on the reproductive system // Microbiol. Mol. Biol. Rev. 2001. Vol. 65. № 2. P. 208-231.
  26. Dobs A. S., Dempsey M. A., Ladenson P. W., Polk B. F. Endocrine disorders in men infected with human immunodeficiency virus //Am. J. Med. 1988. Vol. 84. P. 611-616.
  27. Erpenbach К. H. J Systemic treatment with interferon-alpha 2 B: an effective method to prevent sterility after bilateral mumps orchitis // J. Urol. 1991. Vol. 146. P. 54-56.
  28. Falorni A., Laureti S., De Bellis A. et al. Italian addison network study: update of diagnostic criteria for the etiological classification of primary adrenal insufficiency // J. Clin. Endocrinol. Metab. 2004. Vol. 89. № 4. P. 1598-1604.
  29. Garrel D. R. Corticosteroid-binding globulin during inflammation and burn injury: nutritional modulation and clinical implications // Horm. Res. 1996. Vol. 45. P. 245-251.
  30. Greenberg A. S., McDaniel M. L. Identifying the links between obesity, insulin resistance and b-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes П Eur. J. Clin. Invest. 2002. Vol. 32(Suppl 3). P. 24-34.
  31. Grinspoon S., Corcoran C., Askari H. et al. Effects of androgen administration in men with the AIDS wasting syndrome. A randomized, double-blind, placebo-controlled trial //Ann. Intern. Med. 1998. Vol. 129. P. 18-26.
  32. Harkonen T., Lankinen H., Davydova B. et al. Enterovirus infection can induce immune responses that cross-react with b-cell autoantigen tyrosine phospha¬tase 1A-2/1AR // J. Med. Virol. 2002. Vol. 66. № 3. P. 340-350.
  33. Hiemstra H. S., Schloot N. C., van Veelen P. A. et al. Cytomegalovirus in autoimmunity: T-cell crossreactiv¬ity to viral antigen and autoantigen glutamic acid de¬carboxylase // PNAS. 2001. 'Vol. 98. № 7. P. 3988-3991.
  34. Horwitz M. S., Bradley L M., HarbertsonJ. et al. Diabetes induced by coxsackie virus: Initiation by bystander damage and not molecular mimicry // Nat. Med. 1998. Vol. 4. № 7. P. 781-785.
  35. Horwitz M. S., Ilic A., Fine C et al. Presented antigen from damaged pancreatic b-cells activates autoreactive T cells in virus-mediated autoimmune diabetes // J. Clin. Invest. 2002. Vol. 109. № 1. P. 79-87.
  36. Hotamisligil G. S., Budavari A., Murray D., Spiegel- man В. M. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis-a // J. Clin. Invest. 1994. Vol. 94. P. 1543-1549.
  37. Hydty H, Taylor K. W. The role of viruses in human diabetes H Diabetologia. 2002. Vol. 45. P. 1353-1361.
  38. Hummel M., Schienker M., Fuchtenbusch M., Ziegler A. G. No major association of breast-feeding, vaccinations, and childhood viral diseases with early islet autoimmunity in the German BABYDIAB study // Diabetes Care. 2000. Vol. 23. P. 969-974.
  39. Jun H. S„ Yoon J. W. The role of viruses in type 1 diabetes: two distinct cellular and molecular mechanisms of virus induced diabetes in animals H Diabetologia. 2001. Vol. 44. P. 271-285.
  40. Knobler H., Schattner A. TNF-a, chronic hepatitis C and diabetes: a novel triad // Q. J. M. 2005. Vol. 98(1). P. 1-6.
  41. Knobler H., Schihmanter R, ZifroniA. Increased risk of type 2 diabetes mellitus in non-cirrhotic patients with hepatitis С П Mayo Clin. Proc. 2000. Vol. 75. P. 355-399.
  42. Koga M., Hirumatsu Y., Jimi A. et al. Immunohistochemical analysis of Bcl-2 Bax and Bak expression in thyroid glands of patients with subacute thyroiditis /7 J. Clin. Endocrinol. Metab. 1999. Vol. 84. P. 2221-2225.
  43. Konrad T., Zeuzem S„ Toffolo G. et al. Severity of HCV-induced liver damage alters glucose homeostasis in noncirrhotic patients with chronic HCV infection H Digestion. 2000. Vol. 62. P. 52-59.
  44. Ku J. H., Kim Y H, Jeon Y. S., Lee N. K. The preventive effect of systemic treatment with interferon-alpha2B for infertility from mumps orchitis // B. J. U. Int. 1999. Vol. 84. P. 839-842.
  45. Le Goffic R, Mouchel T., Ruffault A. et al. Mumps virus decreases testosterone production and gamma interferon-induced protein 10 secretion by human leydig cells // J. Virol. 2003. Vol. 77. № 5. P. 3297-3300.
  46. LecubeA., Hernandez C, GenescaJ. etal. High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury Ц Diabetes Care. 2004. Vol. 27. P. 1171-1175.
  47. LecubeA., HernddezC„ GenescaJ., SimdR Glucose abnormalities in patients with hepatitis C virus infection. Epidemiology and pathogenesis // Diabetes Care. 2006. Vol. 29. P. 1140-1149.
  48. Lecube A., Hernandez С, GenescaJ., Simo R. Proin-flammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: a case-control study// Diabetes Care. 2006. Vol. 29. P. 1096-1101.
  49. Licinio J., Frost P. The neuroimrnune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics // Braz. J. Med. Biol. Res. 2000. Vol. 33. P. 1141-1148.
  50. Lonnrot M., Salminen K„ Knip M. et al. Enterovirus RNA is a risk factor for beta cell autoimmunity and clinical IDDM - a prospective study H J. Med. Virol. 2000. Vol. 61. P. 214-220.
  51. LuotolaK., HyotiH., MiettinenA. et al. Evaluation of infectious etiology in subacute thyroiditis - a lack of association with coxsackie virus infection // APMIS. 1998. Vol. 106. P. 500-504.
  52. MqyoM. J. Extrahepatic manifestations of hepatitis C infection//Am. J. Med. Sci. 2003. Vol. 325. P. 135-148.
  53. MehtaS. H., Brancati F. L., Strathdee S. A. et al. Hepatitis C virus infection and incident type 2 diabetes // Hepatology. 2003. Vol. 3 8. P. 50-86.
  54. MehtaS. H., BrancaiiE L., SulkowskiM. S. et al. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States // Ann. Intern. Med. 2000. Vol. 133. P. 592-599.
  55. Minneci P. C., Deans K. J., Banks S. M. et al. Meta-Analysis: The effect of steroids on survival and shock during sepsis depends on the dose // Ann. Intern. Med. 2004. Vol. 141. P. 47-56.
  56. Mori K., Yoshida K., Funato T. Failure in detection of Epstein-Barr virus and cytomegaly virus in specimen obtained by fine needle aspiration biopsy in patients with subacute thyroiditis // Tokohu. J. Exp. Med. 1998. Vol. 186. P. 13-17.
  57. Pariante С. M., Pearce B. D„ Pisell T L. et al. The proinflammatory cytokine, interleukin-1 alpha, reduces glucocorticoid receptor translocation and function И Endocrinology. 1999. Vol. 140. P. 4359-4366.
  58. Peltola H„ Davidkin I., Paunio M. et al. Mumps and rubella eliminated from Finland // JAMA. 2000. Vol. 284. № 20. P. 2643-2647.
  59. Perry R., Kecha O., Paquette J. et al. Primary adrenal insufficiency in children: twenty years experience at the Sainte-Justine Hospital. Montreal // J. Clin. Endo¬crinol. Metab. 2005. Vol. 90. P. 3243-3250.
  60. Petersen L. D., Duinkerken G., Bruining J. et al. Increased numbers of in vivo activated T-cells in patients with recent onset insulin-dependent diabetes mellitus // J. Autoimmun. 1996. Vol. 9. № 6. P. 731-737.
  61. Petit J.-M., BourJ.-B„ Galland-Jos C. et al. Risk factors for diabetes mellitus and early insulin resistance in chronic hepatitis C // J. Hepatol. 2001. Vol. 35. P. 279-283.
  62. Paretsky L., Can S., Zumoff B. Testicular dy sfunction in human immunodeficiency virus-infected men II Metabolism. 1995. Vol. 44. P. 946-953.
  63. Prummel M. E, Strieder T., Wiersinga W. M. The environment and autoimmune thyroid diseases II Europ. J. Endocrinol. 2004. Vol. 150. P. 605-618.
  64. PudneyJ., Anderson D. Orchitis and human immuno¬deficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome П Am. J. Pathol. 1991. Vol. 139. P. 149-160.
  65. Roep В. O. The role of T-cells in the pathogenesis of type 1 diabetes: from cause to cure // Diabetologia. 2003. Vol. 46. № 3. P. 305-321.
  66. Romero-Gomez M., Viloria D. M., Andrade R. J. et al. Insulin resistance impairs sustained response rate to peginterferon plus ribavirin in chronic hepatitis C patients //Gastroenterology. 2005. Vol. 128. P. 636-641.
  67. Ramos-Casals M., Trejo O., Garca-Carrasco M. and Font J.. Therapeutic management of extrahepatic manifestations in patients with chronic hepatitis C virus in¬fection // Rheumatology. 2003. Vol. 42. P. 818-828.
  68. Ruan H., Lodish H. F. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-a // Cytokine Growth Factor Rev. 2003. Vol. 14. P. 447—455.
  69. Schneider U., Birnbacher R., SchickS. et al. Recurrent suppurative thyroiditis due to pyriform sinus fistula // Eur. J. Pediatr. 1995. Vol. 154. P. 640-642.
  70. Sellmeyer D. E., Grunfeld C. Endocrine and metabolic disturbances in human immunodeficiency virus infection and the acquired immune deficiency syndrome // Endocrine Rev. 1996. Vol. 17. P. 518-532.'
  71. Serreze D. V., Ottendorfer E. W., Ellis T M. et al. Ac¬celeration of type 1 diabetes by a coxackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets // Diabetes. 2000. Vol. 49. P. 708-711.
  72. Sharshar T, Annane D., Lorin de la Grandmaison G. et al. The neuropathology of septic shock: a prospective case-control study П Brain Pathology. 2004. Vol. 14. P. 21-33.
  73. Sougleri M., Labropoulou-Karatza C., Paraskevopou- lou P. et al. Chronic hepatitis C virus infection without cirrhosis induces insulin resistance in patients with alpha-thalassaemia major// Eur. J. Gastroenterol. Hepatol. 2001. Vol. 13. P. 1195-1199.
  74. Strieder T. G., Wenzel В. E., Prummel M. E et al. Increased prevalence of antibodies to enteropathogenic Yersinia enterocolitica virulence proteins in relatives of patients with autoimmune thyroid disease H Clin. Exp. Immunol. 2003. Vol. 132. P. 278-282.
  75. Ten S., New M., Maclaren N. Addison’s Disease 2001 // J. Clin. Endocrinol. Metab. 2001. Vol. 86. № 7. P. 2909-2922.
  76. TodaS., Nishimura T., YamadaS. Immunohistochemical expression of growth factors in subacute thyroiditis and their effects on follicogenesis and angiogenesis in collagen gel matric culture // J. Pathol. 1999. Vol. 188. P. 415^122.
  77. Tomer Y., Davies T. F. Infection, thyroid disease, and autoimmunity // Endocrinol. Rec. 1993. Vol. 14. P. 107-120.
  78. Vernazza P. L., Eron J. J., Cohen M. S. et al. Detection and biologic characterization of infectious HIV-i in semen of seropositive men П AIDS. 1994. Vol. 8. P. 1325-1329.
  79. VonHerrath М G. Obstacles to identifying viruses that cause autoimmune disease // J. Neuroimmunol. 2000. Vol. 107. Р. 154-160.
  80. VonHerrath М G., Holz А., Нотапп D., O/dstone М Role of viruses in type I diaЬetes // Semin. lmmunol. 1998. Vol. 10. Р. 87-100.
  81. Wa/ker В. F., Gunthe/ С. J., Bryan J. А. et al. Disseminated cryptococcosis in an apparently normal host presenting as primary adrenal insufficiency: diagnosis Ьу fine needle aspiration // Am. J. Med. 1989. Vol. 86 (6Pt. 1).Р. 715-717.
  82. Wilson W Т., Frenkel Е., Vuitch F., Sagalowsky А. 1 Testicular tumors in men with human immunodeficiency virus // J. Urol. 1992. Vol. 147. Р. 1038-1040.
  83. Yin Н., Berg А. К., Tuvemo Т., Frisk G. Enterovirus RNA is found in peripheral Ыооd mononuclear cells in а majority ofType I diaЬetic children at onset // Diabe¬tes. 2002. Vol. 51. Р. 1964-1971.
  84. Yoshikawa У., Truong L D., Fraire А. Е., Кiт Н. S. The spectrum of histopathology of the testis in acquired immunodeficiency syndrome // Mod. Pathol. 1989. Vol. 2. Р. 233-238.
  85. Zhang Н., Dornadula G., Beumont М et al. Human im¬munodeficiency virus type I in the semen of men receiving highly active antiretroviral therapy // N. Engl. J. Med. 1998. Vol. 339. № 25. Р. 1803-1809.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2008 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.