Interrelatios between hormones and cytokines in regulation of hypothalamus-pituitary-adrenal axsis

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Abstract

The nervous, endocrine and immune systems are anatomically and functionally interconnected. These organ systems both express and respond to a large number of common regulatory molecules including steroids, neuropeptides, cytokines, which provide the molecular basis for integrated, bidirectionally coordinated neuroendocrine-immune responses to homeostasis disturbances induced by stress, inflammation, autoimmune and infection diseases. HPA axsis activation, which under primary hypotalamic control by corticotropin releasing hormone (CRH) is critical for maintaining physiological homeostasis under this circumstances. More recent findings indicate quite subtile but sustained changes in glucocorticoid secretion activity are potentially hazardous and may contribute to the pathogenesis of a number of common diseases, including cardiovascular disease, insulin resistance, autoimmune diseases.

About the authors

S. A. Ketlinskiy

State research Institute of Highly Pure Biopreparations of Federal medical biological agency

Author for correspondence.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, Saint-Petersburg

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