Molecular genetic and pharmacological aspects of steroid resistance in bronchial asthma

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Abstract

The bronchial asthma concerns to group of multifactorial diseases, in pathogenesis which the various functionally interconnected genes are involved. Taking into account genetic heterogeneity of disease, one of approaches to the decision of a question on inheritance is the analysis not a complex phenotype as a whole, and the most essential attributes making it. The patients requiring for hormonal therapy, differ both on sensitive to it, and on frequency of development of numerous by-effects of this therapy. Anti-inflammatory action of glucocorticoids is established by a continuum of the actions regulating экспрессию of a gene in cells, beginning from early events of signaling to the posttransmitting updatings meeting after when the transcription has already taken place. Glucocorticoids raise synthesis of some anti-inflammatory factors and brake formation of proinflammatory fibers. The understanding of molecular mechanisms of development steroid-resistants and actions of anti-inflammatory therapy at patients with a bronchial asthma will allow to predict the answer to action of medical products, and also to promote improvement of principles of individual anti-inflammatory therapy.

About the authors

V. I. Trophimov

Pavlov St. Petersburg State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru

кафедра госпитальной терапии имени М. В. Черноруцкого

Russian Federation, St. Petersburg

Zh. A. Mironova

Pavlov St. Petersburg State Medical University

Email: shabanov@mail.rcom.ru

кафедра госпитальной терапии имени М. В. Черноруцкого

Russian Federation, St. Petersburg

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