Molecular and biological basis of humoral regulation disturbances in diabetes mellitus

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

A review of literature covering the Molecular and biological basis of humoral regulation disturbances in type 1 and type 2 diabetes mellitus. The role of genetic factors, cellular and humoral immunopathologic mechanisms of pancreatic cells damage, state of other parts of endocrine system, neuroendocrine changes and metabolic disturbances are discussed.

About the authors

А. М. Zaichik

St. Petersburg Medical Academy of Postgraduate Studies

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

References

  1. Зайчик А. Ш., Чурилов Л. П. Основы общей патологии. Часть 2. Основы патохимии. СПб.: ЭЛБИ, 2000.
  2. Dotta F., Fondelli С., Di Mario U. Type 1 diabetes mellitus as a polygenic multifactorial disease: immunopathogenic mechanisms of beta-cell destruction // Acta Biomed. 2005. Vol. 76 (Suppl. 3). P. 14-18.
  3. Gerich J. E. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity // Endocrinol. Rev. 1998. Vol. 19. № 4. P. 491-503.
  4. Kim E., Sohn S., Lee M. et al. Differential responses of the growth hormone axis in two rat models of streptozotocin-induced insulinopenic diabetes // J. Endocrinol. 2006. Vol. 188. P. 263-270.
  5. NotkinsA. L., Lernmark A. Autoimmune type 1 diabetes: resolved and unresolved issues // J. Clin. Invest. 2001. Vol. 108. P. 1247-1252.
  6. Owen K. R, McCarthy M. 1. Genetics of type 2 diabetes // Curr. Opin. Genet. Dev. 2007. Vol. 17. № 3. P. 239-244.
  7. Shechter Y., Elias D., Maron R., Cohen I. R Mice immunized to insulin develop antibody to the insulin receptor // J. Cell. Biochem. 1983. Vol. 21. №. 2. P. 179-185.
  8. Shechter Y, Meyerovitch J., Amir S. The use of postbinding agents in studying insulin action and its relation to experimental diabetes // Biochem. Pharmacol. 1988. Vol. 37. №. 10. P. 1891-1896.
  9. Shi Y, Taylor S. I., TanS. L, SonenbergN. When translation meets metabolism; multiple links to diabetes // Endocrinol. Rev. 2003. Vol. 24. № 1. P 91-101.
  10. SprangerJ., KrokeA., Mohlig M. et al. Inflammatory cytokines and the risk to develop type 2 diabetes // Diabetes. 2003. Vol. 52. P. 812-817.
  11. Stoyanovitch A. G., Johnson M. A., Clifton D. K. et al. Galanine-like peptide rescues reproductive function in the diabetic rat // Diabetes. 2005. Vol. 54. P. 2471-2476.
  12. Tardella L., Rossetti L., De Pirro R et al. Circulating anti-insulin receptor antibodies in a patient suffering from lupus nephritis and hypoinsulinemic hypoglycae¬mia // J. Clin. Lab. Immunol. 1983. Vol. 12. № 3. P. 159-165.
  13. Zelena D., Filaretova L., Mergl Z. et al. Hypothalamic paraventricular nucleus, but not vasopressin, participates in chronic hyperactivity of the HPA axis in diabetic rats //Am. J. Physiol. Endocrinol. Metab. 2006, Vol. 290. P. E243-E250.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2008 Eco-Vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.