Генитальная папилломавирусная инфекция: биологические и клинические аспекты

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Аннотация

Выявление взаимосвязи между папилломавирусной (human papilloma virus, HPV) инфекцией и раком шейки матки (РШМ) является одним из самых социально-значимых достижений молекулярной онкологии. Доказано, что HPV играют ключевую роль в патогенезе практически всех случаев РШМ. Следует оговориться, что само по себе присутствие папилломавируса не является достаточным условием для возникновения онкологического заболевание. Бессимптомное носительство HPV наблюдается примерно у 30 % здоровых женщин репродуктивного возраста. Выявление HPV-инфицированных лиц позволяет рационализировать мероприятия по профилактике и ранней диагностике РШМ. К настоящему времени во всех развитых странах, в т ч. и в России, проводятся широкомасштабные скрининговые программы, направленные на детекцию HPV. В качестве основных методов выявления HPV выступают молекулярногенетические, главным образом полимеразная цепная реакция (ПЦР). Предполагается, что в недалёкой перспективе успехи в диагностике папилломавирусов будут дополнены достижениями в HPV-вакцинации.

Об авторах

Ю. Н. Александрова

Научно-исследовательский институт онкологии имени проф. Н. Н. Петрова

Автор, ответственный за переписку.
Email: shabanov@mail.rcom.ru
Россия, Санкт-Петербург, 197758, пос. Песочный-2, ул. Ленинградская, 68

Е. Н. Имянитов

Научно-исследовательский институт онкологии имени проф. Н. Н. Петрова

Email: shabanov@mail.rcom.ru
Россия, Санкт-Петербург, 197758, пос. Песочный-2, ул. Ленинградская, 68

К. П. Хансон

Научно-исследовательский институт онкологии имени проф. Н. Н. Петрова

Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Россия, Санкт-Петербург, 197758, пос. Песочный-2, ул. Ленинградская, 68

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