Роль инфекционно-воспалительного фактора в развитии атеросклероза

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Аннотация

В обзоре представлены данные по влиянию инфекционных агентов и медиаторов воспаления на развитие атеросклероза. Известно, что воспаление сосудистого русла играет важную роль в патогенезе атеросклероза. Клинические исследования показали наличие корреляции между уровнем концентрации маркеров воспаления и вероятностью развития коронарных событий. Один из триггер-факторов, вызывающих системное воспаление, хроническая или острая инфекция. Взаимосвязь инфекции и атерогенеза является весьма сложной. Результаты соответствующих исследований противоречивы, в том числе и из-за методологических проблем. Очевидно, вероятность развития и течения атеросклероза в большей степени зависит от общего количества инфицирующих патогенов («патогенной нагрузки»), чем от инфицирования, тем или иным конкретным патогеном.

Об авторах

Ю. В. Лобзин

Российская военно-медицинская академия

Автор, ответственный за переписку.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Россия, 194175, Санкт- Петербург, ул. Академика Лебедева, 6

А. В. Рудакова

Российская военно-медицинская академия

Email: shabanov@mail.rcom.ru
Россия, 194175, Санкт- Петербург, ул. Академика Лебедева, 6

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