Antiviral activity of interferon inducer amixin

An antiviral property of a low molecular interferon inducer - amixin has been analyzed on in vitro models of influenza virus infection in tissue culture. As a result of our investigations it was revealed that amixin has a direct effect on RNA virus reproduction (e. g., influenza viruses) and inhibits a synthesis of viral nucleic acids. Moreover, amixin is equally active as for rimantadine-resistant influenza viruses type A, so as for influenza viruses type B, that is characterized by naturally occurring amantadine and rimantadine resistance. Amixin belongs to the preparations that succesfully combine interferon-inducing activity and direct antiviral effect, that could be considered as an advantage comparing with cycloferon and neovir. However, amixin demonstrates high cytotoxicity thus calling for improvement of its therapeutic efficacy. New antiviral derivatives of fluorenone and improvement of amixin biological characteristics development can be reached by introduction of specific substitutions into symmetrical aminoethoxigroups.