Free radical and antioxidant processes in hemophilia

The state of the oxidant - antioxidant system was studied in 80 patients: 25 patients were with moderate hemophilia and 55 patients with severe hemophilia. Some lipid peroxidation parameteres - the contents of diene and triene conjugates, malonyl dialdehyde in blood serum, as well as antioxidant system - the activities of superoxide dismutase, glutathione peroxidase, catalase, the contents of ceruloplasmin and nonprotein thiole groups demonstrating the level of reduced glutathione, were estimated. It was shown that the formation of lipid peroxides has not been balanced by the functioning of antioxidant system. The latter is being particularly aggravated in severe hemophilia. Approximately 2-fold elevation of lipid peroxidation products was noted together with the decrease of glutathione peroxidase activity, the contents of reduced glutathione and ceruloplasmin in recurrent bleedings. The above is confirmed by the alteration of the activity of superoxide dismutase and catalase: 3-fold decreased SOD/CAT coefficient in comparison with normal. The role of «oxidative stress» in pathogenesis of hemophilia and the significance of correction of antioxidant status by means of introducing the antioxidant remedies for treating hemofiliac patients is being discussed.