MASS SPECTROMETRY IN MEDICINE



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Abstract

Techniques of mass spectrometric analyses are briefly considered, its fields of application in medical research and clinical diagnostics are reviewed. The determination of biomarkers is discussed. The fields of diagnostics in which mass spectrometry plays an important role, namely, human breath analysis, newborn screening, identification of microorganisms, endocrinology, drug therapy, peptide and protein markers, and mass spectrometric visualization, are characterized.

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About the authors

B L Milman

Institute of Experimental Medicine

I K Zhurkovich

Institute of Toxicology

References

  1. Jannetto P.J., Fitzgerald R.L. Effective use of mass spectrometry in the clinical laboratory // Clinical chemistry. 2016. Vol. 62. No 1. P. 92-98.
  2. Vékey K., Telekes A., Vertes A. (еds.). Medical applications of mass spectrometry. Amsterdam: Elsevier, 2008. 606 p.
  3. Garg U., Hammett-Stabler H. (еds.). Clinical applications of mass spectrometry. Methods and Protocols. New York: Humana Press, 2010. 540 p.
  4. Мильман Б.Л., Журкович И.К. Масс-спектрометрический анализ медицинских объектов и проблемы клинической диагностики // Журнал аналитической химии. 2015. Т. 70, № 10. С. 1026-1039 [Mil’man B.L., Zhurkovich I.K., Zhurnal analiticheskoi khimii, 2015. Vol. 70. No. 10. pp. 1026-1039].
  5. Clinical chemistry. 2016. Vol. 62. No 1.
  6. Trends in analytical chemistry. 2016. Vol. 84.
  7. Мильман Б.Л., Утсаль В.А., Луговкина Н.В., Котряхов И.А., Журкович И.К. Сравнительное определение жирнокислотного состава низкомолекулярных компонентов плазмы крови тремя методами масс-спектрометрии: «старо-новое упражнение по липидомике // Масс-спектрометрия. 2015. Т. 12, № 2. С. 73-84 [Mil’man B.L., Utsal’ V.A., Lugovkina N.V., Kotryakhov I.A., Zhurkovich I.K., Mass-spektrometriya, 2015, vol. 12, No. 2, pp. 73-84].
  8. Мильман Б.Л., Ильясов Ю.Ю., Луговкина Н.В., Головина А.А., Дмитриев А.В. «Низкомолекулярный» подход к идентификации микроорганизмов методом масс-спектрометрии МАЛДИ // Масс-спектрометрия. 2016. Т. 13, № 3. С. 158-167 [Mil’man B.L., Il’yasov Yu.Yu., Lugovkina N.V., Golovina А.А., Dmitriev А.V., Mass-spektrometriya. 2016. Vol. 13. No. 3. pp. 158-167].
  9. Shushan B. A review of clinical diagnostic applications of liquid chromatography-tandem mass spectrometry // Mass spectrometry reviews. 2010. Vol. 29. No 6. P. 930-944.
  10. Metabolomics. Электронный ресурс https://en.wikipedia.org/wiki/Metabolomics (дата обращения 19.03.2017).
  11. Proteomics. Электронный ресурс https://en.wikipedia.org/wiki/Proteomics (дата обращения 19.03.2017).
  12. Madsen R., Lundstedt T., Trygg J. Chemometrics in metabolomics-a review in human disease diagnosis // Analytica chimica acta. 2010. Vol. 659, No 1. P. 23-33.
  13. Anderson L. Within sight of a rational pipeline for development of protein diagnostics // Clinical chemistry. 2012. Vol. 58, No 1. P. 28-30.
  14. Parker C.E., Borchers C.H. Mass spectrometry based biomarker discovery, verification, and validation-quality assurance and control of protein biomarker assays // Molecular oncology. 2014. Vol. 8, No 4. P. 840-858.
  15. Liesenfeld D.B., Habermann N., Owen R.W., Scalbert A., Ulrich C. M. Review of mass spectrometry-based metabolomics in cancer research // Cancer epidemiology and prevention biomarkers. 2013. Vol. 22, No 12. P. 2182-2201.
  16. Johnson C. H., Ivanisevic J., Siuzdak G. Metabolomics: beyond biomarkers and towards mechanisms // Nature reviews molecular cell biology. 2016. Vol. 17, No 7. P. 451-459.
  17. Gillespie T. A., Winger B. E. Mass spectrometry for small molecule pharmaceutical product development: a review // Mass spectrometry reviews. 2011. Vol. 30, No 3. С. 479-490.
  18. Görög S. Identification in drug quality control and drug research // Trends in analytical chemistry. 2015. Vol. 69. P. 114-122.
  19. Rentsch K.M. Knowing the unknown - State of the art of LCMS in toxicology // Trends in analytical chemistry. 2016. Vol. 84. P. 88-93.
  20. Kushnir M.M., Rockwood A.L., Bergquist J. Liquid chromatography-tandem mass spectrometry applications in endocrinology // Mass spectrometry reviews. 2010. Vol. 29, No 3. P. 480-502.
  21. Medical laboratory sciences. Электронный ресурс http://www.mayo.edu/mayo-clinic-school-of-health-sciences/careers/laboratory-sciences (дата обращения 19.03.2017).
  22. Meng Q.H. Mass spectrometry applications in clinical diagnostics // Journal of clinical and experimental pathology suppl. 2013. Vol. 6. P. e001.
  23. Vogeser M., Seger C. Mass spectrometry methods in clinical diagnostics-state of the art and perspectives // Trends in analytical chemistry. 2016. Vol. 84. P. 1-4.
  24. Журкович И.К., Мильман Б.Л. Общая характеристика современных методик анализа. Пример масс-спектрометрии и хромато-масс-спектрометрии // Журнал аналитической химии. 2009. Т. 64, № 10. С. 1012-1021 [Mil’man B.L., Zhurkovich I.K., Zhurnal analiticheskoi khimii. 2009. Vol. 64. No. 10. pp. 1012-1021].
  25. Bouillon R. The power of mass spectroscopy as arbiter for immunoassays // Clinical chemistry. 2016. Vol. 62, No 1. P. 6-8.
  26. Saint-Marcoux F., Sauvage F.L., Marquet P. Current role of LC-MS in therapeutic drug monitoring // Analytical and bioanalytical chemistry. 2007. Vol. 388, No 7. P. 1327-1349.
  27. Clinical mass spectrometry worldwide market overview. Электронный ресурс http://www.notey.com/@prsync_unofficial/external/14218667/clinical-mass-spectrometry-worldwide-market-overview-by-region-type-application-and-forecast-to-2021.html (дата обращения 20.03.2017).
  28. Степанов Е.В. Методы высокочувствительного газового анализа молекул-биомаркеров в исследованиях выдыхаемого воздуха // Труды института общей физики им. А.М. Прохорова. 2005. Т. 61. С. 5-47 [Stepanov E.V., Trudy instituta obschei fiziki im. A.M. Prokhorova. 2005. Vol. 61. pp. 5-47].
  29. Modak A.S. Regulatory issues on breath tests and updates of recent advances on [13C]-breath tests // Journal of breath research. 2013. Vol. 7, No 3. P. 037103.
  30. Yoshida M., Hatano N., Nishiumi S., Irino Y., Izumi Y., Takenawa T., Azuma T. Diagnosis of gastroenterological diseases by metabolome analysis using gas chromatography-mass spectrometry // Journal of gastroenterology. 2012. Vol. 47, No 1. P. 9-20.
  31. Beck O., Olin A.C., Mirgorodskaya E. Potential of mass spectrometry in developing clinical laboratory biomarkers of nonvolatiles in exhaled breath // Clinical chemistry. 2016. Vol. 62, No 1. P. 84-91.
  32. Modak A.S. Stable isotope breath tests in clinical medicine: a review // Journal of breath research. 2007. Vol. 1, No 1. P. 014003.
  33. Charrow J., Goodman S.I., McCabe E.R.G., Rinaldo P. Tandem mass spectrometry in newborn screening // Genetics in medicine. 2000. Vol. 2. No 4. P. 267-269.
  34. Chace D.H., Kalas T.A., Naylor E.W. Use of tandem mass spectrometry for multianalyte screening of dried blood specimens from newborns // Clinical chemistry. 2003. Vol. 49. No 11. P. 1797-1817.
  35. Rousseau F. Guérette D., Girard J. G., Berthier M. T., Déry M., Giguère Y. Newborn screening by tandem mass spectrometry: impacts, implications and perspectives. Электронный ресурс http://cdn.intechweb.org/pdfs/29024.pdf (дата обращения 20.03.2017).
  36. Mak C.M., Lee H.C.H., Chan A.Y.W., Lam C.W. Inborn errors of metabolism and expanded newborn screening: review and update // Critical reviews in clinical laboratory sciences. 2013. Vol. 50. No 6. P. 142-162.
  37. Осипов Г.А., Демина А.М. Хромато-масс-спектрометрическая индикация микроорганизмов в анаэробных инфекционных процессах // Вестник РАМН. 1996. Т. 13, № 2. С. 15-27 [Osipov G. A., Demina A.M., Vestnik RAMN. 1996. Vol. 13. No. 2. pp. 15-27].
  38. Inglis T. J. J. Aravena-Roman M., Ching S., Croft K., Wuthiekanun V., Mee B. J. Cellular fatty acid profile distinguishes Burkholderia pseudomallei from avirulent Burkholderia thailandensis // Journal of clinical microbiology. 2003. Vol. 41. No 10. P. 4812-4814.
  39. Li D., March J.K., Bills T.M., Holt B.C., Wilson C.E., Lowe W., Tolley H.D., Lee M.L., Robison R.A. Gas chromatography-mass spectrometry method for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei from each other, Burkholderia thailandensis and several members of the Burkholderia cepacia complex // Journal of applied microbiology. 2013. Vol. 115. No 5. P. 1159-1171.
  40. Slabbinck B., De Baets B., Dawyndt P., De Vos P. Towards large-scale FAME-based bacterial species identification using machine learning techniques // Systematic and applied microbiology. 2009. Vol. 32. No 3. P. 163-176.
  41. Sauer S., Kliem M. Mass spectrometry tools for the classification and identification of bacteria // Nature reviews microbiology. 2010. Vol. 8. No 1. P. 74-82.
  42. Van Belkum A., Welker M., Erhard M., Chatellier S. Biomedical mass spectrometry in today's and tomorrow's clinical microbiology laboratories // Journal of clinical microbiology. 2012. Vol. 50, No 5. P. 1513-1517.
  43. Khot P.D., Fisher M.A. Mass spectrometry in the clinical microbiology laboratory, Part I: PCR-MS // Clinical microbiology newsletter. 2012. Vol. 34, No 17. P. 135-140.
  44. Grebe S.K., Singh R.J. LC-MS/MS in the clinical laboratory - where to from here // The Clinical biochemist reviews. 2011. Vol. 32, No 1. P. 5-31.
  45. Shipkova M., Valbuena H. Liquid chromatography tandem mass spectrometry for therapeutic drug monitoring of immunosuppressive drugs: Achievements, lessons and open issues // Trends in analytical chemistry. 2016. Vol. 84. P. 23-33.
  46. Veringa A., Sturkenboom M.G., Dekkers B.G., Koster R.A., Roberts J.A., Peloquin C.A., Touw D.J., Alffenaar J.W. C. LC-MS/MS for therapeutic drug monitoring of anti-infective drugs // Trends in analytical chemistry. 2016. Vol. 84. P. 34-40.
  47. Douxfils J., Pochet L., Lessire S., Vancraeynest C., Dogné J. M., Mullier F. Mass spectrometry in the therapeutic drug monitoring of direct oral anticoagulants. Useful or useless? // Trends in analytical chemistry. 2016. Vol. 84. P. 41-50.
  48. Indovina P., Marcelli E., Pentimalli F., Tanganelli P., Tarro G., Giordano A. Mass spectrometry-based proteomics: The road to lung cancer biomarker discovery // Mass spectrometry reviews. 2013. Vol. 32, No 2. P. 129-142.
  49. Cho Y. T., Su H., Huang T.L., Chen H.C, Wu W.J., Wu P.C., Wu D.C., Shiea J. Matrix-assisted laser desorption ionization/time-of-flight mass spectrometry for clinical diagnosis // Clinica chimica acta. 2013. Vol. 415. P. 266-275.
  50. Savaryn J.P., Catherman A.D., Thomas P.M., Abecassis M.M., Kelleher N. L. The emergence of top-down proteomics in clinical research // Genome medicine. 2013. Vol. 5, Nо 6. P. 53.
  51. Grebe S.K.G., Singh R.J. Clinical peptide and protein quantification by mass spectrometry (MS) // Trends in analytical chemistry. 2016. Vol. 84. P. 131-143.
  52. Schöne C., Höfler H., Walch A. MALDI imaging mass spectrometry in cancer research: combining proteomic profiling and histological evaluation // Clinical biochemistry. 2013. Vol. 46, Nо 6. P. 539-545.
  53. Norris J.L., Caprioli R.M. Imaging mass spectrometry: a new tool for pathology in a molecular age // PROTEOMICS - Clinical Applications. 2013. Vol. 7, No 11-12. P. 733-738.
  54. McDonnell L.A., Angel P.M., Lou S., Drake R.R. Mass spectrometry imaging in cancer research: Future perspectives // Advances in cancer research. 2016. Vol. 134. P. 283-289.
  55. Лебедев А.Т. Масс-спектрометрия c ионизацией на воздухе // Успехи химии. 2015. Т. 84, № 7. С. 665-692 [Lebedev А.T., Uspekhi khimii. 2015. Vol. 84, No. 7. pp. 665-692].
  56. Ferreira C.R., Yannell K.E., Jarmusch A.K., Pirro V., Ouyang Z., Cooks R.G. Ambient ionization mass spectrometry for point-of-care diagnostics and other clinical measurements // Clinical chemistry. 2016. Vol. 62, No 1. P. 99-110.
  57. Ifa D.R., Eberlin L. S. Ambient ionization mass spectrometry for cancer diagnosis and surgical margin evaluation // Clinical chemistry. 2016. Vol. 62, No 1. P. 111-123.
  58. Van den Ouweland J.M.W. Analysis of vitamin D metabolites by liquid chromatography-tandem mass spectrometry // Trends in analytical chemistry. 2016. Vol. 84. Р. 117-130.
  59. Lynch K.L. CLSI C62-A: a new standard for clinical mass spectrometry // Clinical chemistry. 2016. Vol. 62, No 1. P. 24-29.
  60. Lathrop J.T., Jeffery D.A., Shea Y.R., Scholl P.F., Chan M.M. US Food and Drug Administration perspectives on clinical mass spectrometry // Clinical chemistry. 2016. Vol. 62, No 1. P. 41-47.
  61. Журкович И.К, Мильман Б.Л. Аналитические приборы в биологии и медицине: мировые тренды, ситуация в России // Тезисы докладов 4-й Всероссийской конференции «Аналитические приборы”. Санкт-Петербург, 26-30 июня 2012 г. [Zhurkovich I.K., Mil’man B.L., Tezisy dokladov 4 Vserossiiskoi konferentsii «Analiticheskie pribory», Iyun’ 26-30, 2012, Saint-Petersburg].

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