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To date, the expression of bitter taste receptors in the respiratory system (in particular, on the human smooth muscle cells of bronchi, on the epithelial cells of the lungs), as well as on lymphocytes, macrophages, mast cells and other cells. In many ways, the function of these receptors to bitter taste (TAS2R) is not yet clear. Possible ways of involvement of the TAS2R-signaling system in the pathogenesis of bronchial asthma are discussed. The involvement of TAS2R in the bronchi smooth muscle relaxation, inhibition of the production of inflammatory mediators is considered. TAS2R is expressed on mobile cilia of human bronchial epithelial cells, giving them chemosensory properties. The presence of the TAS2R-signaling system in the cilia gives them autonomy regarding the identification of a harmful signal (bitter substance) followed by the elimination of this dangerous substance by these cells. The role of TAS2R in mucociliary clearance, production of nitric oxide (NO), a direct antibacterial effect, an individual predisposition to respiratory infection is studied. Possible involvement of TAS2R in the pathogenesis of inflammation at the level of the upper respiratory tract, especially in rhinosinusitis, is discussed. Further development of the problem promises discoveries, both in the development of new therapeutic approaches in bronchial asthma, and in the understanding at a new level of the common, fundamental processes that underlie the diverse pathology associated with the oldest protective sensory system - the gustatory system.



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About the authors

V N Mineev

Pavlov First St. Petersburg State Medical University

A A Kuzikova

Pavlov First St. Petersburg State Medical University

M A Nyoma

Pavlov First St. Petersburg State Medical University


  1. Deshpande D.A., Wang W.C., McIlmoyle E.L., Robinett K.S., Schillinger R.M., An S.S., Sham .JS., Liggett S.B. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction // Nat. Med. 2010. Vol. 16. P. 1299-1304.
  2. Ekoff M., Choi J.H., James A., Dahlén B., Nilsson G., Dahlén S.E. Bitter taste receptor (TAS2R) agonists inhibit IgE-dependent mast cell activation // J. Allergy Clin. Immunol. 2014. Vol. 134, No 2. P. 475-478.
  3. Grassin-Delyle S., Naline E., Devillier P. Taste receptors in asthma // Curr. Opin. Allergy Clin. Immunol. 2015. Vol. 15, No 1. P. 63-69.
  4. Liggett S.B. Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators // Expert Opin. Ther. Targets. 2013. Vol. 17, No 6. P. 721-731.
  5. Shaik F.A., Singh N., Arakawa M., Duan K., Bhullar R.P., Chelikani P. Bitter taste receptors: Extraoral roles in pathophysiology // Int. J. Biochem. Cell Biol. 2016. Vol. 77. P. 197-204.
  6. Devillier P., Naline E., Grassin-Delyle S. The pharmacology of bitter taste receptors and their role in human airways // Pharmacol. Ther. 2015. Vol. 155. P. 11-21.
  7. Meyerhof W., Batram C., Kuhn C., Brockhoff A., Chudoba E., Bufe B., Appendino G., Behrens M. The molecular receptive ranges of human TAS2R bitter taste receptors // Chem. Senses. 2010. Vol. 35, No 2. P. 157-170.
  8. Robinett K.S., Deshpande D.A., Malone M.M., Liggett S.B. Agonist promoted homologous desensitization of human airway smooth muscle bitter taste receptors // Am. J. Respir. Cell Mol. Biol. 2011. Vol. 45. P. 1069-1074.
  9. Rasmussen T.B., Givskov M. Quorum-sensing inhibitors as anti-pathogenic drugs // Int. J. Med. Microbiol. 2006. Vol. 296, No 2-3. P. 149-161.
  10. Sbarbati A., Tizzano M., Merigo F., Benati D., Nicolato E., Boschi F., Cecchini M.P., Scambi I., Osculati F. Acyl homoserine lactones induce early response in the airway // Anat. Rec. (Hoboken). 2009. Vol. 292, No 3. P. 439-448.
  11. James A., Daham K., Dahlén B., Hedlin, G, Kere, J., Konradsen J., Nordlund B., Lindeberg A., Melen E., Orsmark-Pietras C., Söderhäll C., Pulkkinen V., Dahlen S.-E. K. Expression of bitter taste receptors on peripheral blood leukocytes from asthmatic patients // Am. J. Respir. Crit. Care Med. 2012. Vol. 185. P. A6752.
  12. Orsmark-Pietras C., James A., Konradsen J.R., Nordlund B., Söderhäll C., Pulkkinen V., Pedroletti C., Daham K., Kupczyk M., Dahlén B., Kere J., Dahlén S.E., Hedlin G., Melén E. Transcriptome analysis reveals upregulation of bitter taste receptors in severe asthmatics // Eur. Respir. J. 2013. Vol. 42. P. 65-78.
  13. Shah A.S., Ben-Shahar Y., Moninger T.O., Kline J.N., Welsh M.J. Motile cilia of human airway epithelia are chemosensory // Science. 2009. Vol. 325, No 5944. P. 1131-1134.
  14. Одиреев А.Н., Чжоу С.Д., Ли Ц., Колосов В.П., Луценко М.Т. Нарушения мукоцилиарного клиренса при бронхиальной астме // Бюл. физ. и пат. дых. 2010. Вып. 37. С. 15-21. [Odireev A.N., CHzhou S.D., Li C., Kolosov V.P., Lucenko M.T. Narusheniya mukociliarnogo klirensa pri bronhial'noj astme, Byul. fiz. i pat. dyh. 2010. Vol. 37. рр. 15-21.]
  15. Lee R.J., Cohen N.A. Taste receptors in innate immunity // Cell Mol. Life Sci. 2015. Vol. 72, No 2. P. 217-236.
  16. Douglas J.E., Cohen N.A. Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease // Int. J. Mol. Sci. 2017. Vol. 18, No 2. P. 437.
  17. Adappa N.D., Zhang Z., Palmer JN., Kennedy D.W., Doghramji L., Lysenko A., Reed D.R., Scott T., Zhao N.W., Owens D., Lee R.J., Cohen N.A. The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery // Int. Forum Allergy Rhinol. 2014. Vol. 4, No 1. P. 3-7.
  18. Carey R.M., Lee R.J., Cohen N.A. Taste Receptors in Upper Airway Immunity // Adv. Otorhinolaryngol. 2016. Vol. 79. P. 91-102.
  19. Maurer S., Wabnitz G.H., Kahle N.A., Stegmaier S., Prior B., Giese T., Gaida M.M., Samstag Y., Hänsch G.M. Tasting Pseudomonas aeruginosa biofilms: human neutrophils express the bitter receptor T2R38 as sensor for the quorum sensing molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone // Front. Immunol. 2015. Vol. 6. P. 369.
  20. Lee R.J., Xiong G., Kofonow J.M., Chen B., Lysenko A., Jiang P., Abraham V., Doghramji L., Adappa N.D., Palmer J.N., Kennedy D.W., Beauchamp G.K., Doulias P.T., Ischiropoulos H., Kreindler J.L., Reed D.R., Cohen N.A. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection // J. Clin. Invest. 2012. Vol. 122, No 11. P. 4145-4159.
  21. Cohen N.A. The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis // Laryngoscope. 2017. Vol. 127, No 1. P. 44-51.
  22. Минеев В.Н., Супранович И.Ю. Вкусовая чувствительность к хлориду натрия и калия и некоторые показатели натриевого обмена у больных бронхиальной астмой // Клин. мед. 2008. № 10. С. 32-36. [Mineev V.N., Supranovich I.Yu. Vkusovaya chuvstvitel'nost' k hloridu natriya i kaliya i nekotorye pokazateli natrievogo obmena u bol'nyh bronhial'noj astmoj, Klin. med. 2008. No 10. рр. 32-36.]
  23. Spina D. Current and novel bronchodilators in respiratory disease // Curr. Opin. Pulm. Med. 2014. Vol. 20, No 1. P. 73-86.
  24. Минеев В.Н. Континуумы в клинической медицине // Мед. акад. журн. 2016. Т. 16, № 3. С. 19-28. [Mineev V.N. Kontinuumy v klinicheskoj medicine, Med. akad. zhurn. 2016. Vol. 16. No 3. рр. 19-28.]
  25. Kinnamon S.C. Taste receptor signalling - from tongues to lungs // Acta Physiol. (Oxf). 2012. Vol. 204, No 2. P. 158-168.



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