MODERN CONCEPTS OF THE PATHOGENESIS, RISK FACTORS, AND APPROACHES TO THE TREATMENT OF POSTSTROKE DEPRESSION
- Authors: Belokoskova SG1, Tsikunov SG1
-
Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 16, No 2 (2016)
- Pages: 21-31
- Section: Articles
- Published: 15.06.2016
- URL: https://journals.eco-vector.com/MAJ/article/view/9493
- DOI: https://doi.org/10.17816/MAJ16221-31
- ID: 9493
Cite item
Abstract
The review addresses up-do-date data about the pathogenesis and pathophysiology of poststroke depressive conditions. The neurobiological and psychological hypotheses of the development of depressive states after stroke are considered. The significance of brain lesion localization and size, neuromediator disbalance, neurotrophic factor deficit, immune system activation, hypothalamus-pituitary-adrenal system hyperactivity, disturbed neurogenesis, reduced brain blood flow, and personal traits and peculiarities of responses to stress are discussed. The likely trends of the further studies of risk factors of depressive conditions after stroke and of therapy for such conditions are delineated.
Keywords
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About the authors
S G Belokoskova
Institute of Experimental Medicine
Email: belokoskova.s@yandex.ru
St. Petersburg, Russia
S G Tsikunov
Institute of Experimental Medicine
Email: secikunov@yandex.ru
St. Petersburg, Russia
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