SERUM LEVELS LEUKEMIA INHIBITORY FACTOR PLAYS A CRUCIAL ROLE IN THE PROGRESSION TO ESSENTIAL HYPERTENSION

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Abstract


The aim of the present study was to evaluate the prognostic value of LIF levels in patients with еssential hypertension (EH). Methods: serum LIF, IGF-1 and IGFBP1 levels were measured with an enzyme-linked immunosorbent assay in 200 patients with II stage ЕН during 3 year period. Results: The mean serum LIF concentration in patients with ЕН was significantly higher than that in control subjects (7,54 pg/ml л - 95% confidence interval [7,34-7,74] pg/ml vs 1,25 pg/ml - 95% confidence interval [1,20-1,31] pg/ml, p<0,001). Thus, level LIF and associated IGF-1/IGFBP1 play a critical role in the progression to arterial hypertension (adverse vascular remodeling and cardiac hypertrophy), but the association showed a different pattern for men and women. Logistic regression analysis showed that LIF concentrations were the independent predictors of future events. The three year survival free of stroke and myocardial infarction were significantly lower in patients with LIF concentrations in the III-IV quartiles (7,55-15,5 pg/ml) and IGF-1concentrations in the lowest quartile (values <113 ng/ml) than in those with values <7,5 pg/ml and more 113 pg/ml. Conclusions. We reported a significant association between high serum LIF levels and risk of cardiovascular events (myocardial infarction, stroke) in patients with ЕН. LIF serum concentration may serve as prognosis criteria for progression to ЕН.

O A Radaeva

Mordovian State N. P. Ogariov University

Email: radaevamed@mail.ru

A S Simbirtsev

State Research Institute of Highly Pure Biopreparations

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