I sincerely congratulate Dr. Korneva’s 85 th anniversary. It was my great honor to be invited to contribute to this journal. It was just 20 years ago when I made a conversation with Dr. Korneva in Japan in 1994, who was one of the pioneers in neuroimmunomodulation study in the world. Then I was invited to visit St. Petersburg in 1998 during International Congress of Pathophysiology held in Lahti, Finland. According to her invitation I visited St. Petersburg for the first time to attend International Conference on «Mechanisms of Functioning of Visceral Systems» dedicated to academician Ivan Pavlov’s 150-anniversary. Since that time I visited St. Petersburg many times as well as other cities in Russia such as Moscow, Volgograd and Ekaterinburg. In this short chapter to appreciate Dr. Korneva s sincere kindness, I would like to describe wonderful memories with Dr. Korneva in Russia.

First meeting with Dr. Korneva in Japan. In 1994, the 2nd International Congress of Pathophysiology was held in Kyoto, Japan, from Nov. 19 to 24, of which president was Dr. Y. Oomura, an old friend of Dr. H. Korneva inviting her to this congress. Dr. Oomura was my first professor of physiology in Kyushu University. Just after the congress in Kyoto I moved to Nagoya to attend the 4th Naito Conference on Neuro-Immuno-Endocrine Networks from Nov. 25 to 28. This international conference was organized by Dr. T. Hori, who was my second professor of physiology in Kyushu University. Since Dr. Korneva was also invited by Dr. Hori to attend the conference, I was asked by Dr. Hori to meet Dr. Korneva at Nagoya station. That was the first time to meet with Dr. Korneva. She was a so gentle woman and I was glad to help her to buy something for her family. Of course there was a chance to meet before the congress. In 1990 and 1993, the International Congresses of International Society for Neuroimmunomodulation were held in Florence and Paestum, respectively, Italy, and Dr. Korneva must be there because she was one of the founders of the society. Although I also attended the congress, I could not meet her in those years. Invitation to visit St. Petersburg from Dr. Korneva. In 1998 the 3rd International Congress of Pathophysiology was held at Lahti, Finland. During the congress I met Dr. Korneva and Dr. E. Rybakina with Dr. Y. Oomura. Then Dr. Korneva invited me to visit St. Petersburg to attend the International Conference «Mechanisms of Functioning of Visceral Systems» (dedicated to Academician Ivan Pavlov’s 150-anniversary) held in 1999. Since I was glad to be invited to visit world МЕДИЦИНСКИЙ АКАДЕМИЧЕСКИЙ ЖУРНАЛ, 2014 г., ТОМ 14, № 4 39 wide famous city, St. Petersburg for the first time, I immediately agreed with her invitation. It was an interesting trip because I took train from Helsinki, Finland, to St. Petersburg in 1999. When I arrived at the Finland station in St. Petersburg, Dr. Rybakina and her husband kindly came to the station to pick me up at late evening. It was also an interesting short drive from the station to their home because the town was lighted-up and the whole city seemed to be like a museum. They kindly gave a room in their home and I spent several days. During the conference the postgraduate student, Ms. I. Pivanovich translated the papers presented by the Russian scientists into English because most of the presentation was done in Russian language. In this conference in 1999, I presented a paper about hypothalamic modulation of NK cell activity [4-6]. She also took me to the famous places in St. Petersburg such as Nevsky Prospect, Hermitage Museum, St. Isaac’s Cathedral, Church of the Savior on Blood, Peter and Paul Fortress and the Peterhof. In 2000, I invited Dr. Rybakina to my laboratory in Kyushu University, Fukuoka, Japan to do some collaboration studies. I believe that she enjoyed life in Japan although it was only one month. Thereafter from 2001 until present I was invited by Dr. Korneva to visit Russia totally 9 times. Congress on the ship. The trip to Russia in 2001 was the longest and most exciting one. First I visited St. Petersburg to meet Dr. Korneva and Dr. Rybakina then we together took a train leaving for Volgograd. We started at St. Petersburg in the late night and spent one more night in the train then we arrived at Volgograd early in the morning. I remember that Dr. Korneva told me that I would see the center of Russia during the train journey. In fact I was so surprised by huge land and beautiful nature. In one station we bought a basket of steamed potatoes and enjoyed them. When the train got near to Volgograd in the very early morning, I was impressed by the big stature of Mamaev Kurgan, the symbol of Volgograd, on the hill. Then we visited the dean of the Volgograd University, who used to be a student of Dr. Korneva. He showed us an old book that was hand-written by Leonardo da Vinci. At night I experienced for the first time that I ate a whole, steamed and delicious sturgeon from Volga River. In the next morning we took a 4 storied big cruise ship, named Dmitri Furmanov, on which our symposium, «Reactions of Biological Systems to the Unfavorable Environmental Factors» in the International Conference on Environmental Pollution was held during 7 nights going up from Volgograd to Perm. My presentation in the symposium on the heat exposure-induced bacterial translocation in the aged rat brain [7] was successful and I awarded an excellent paper prize in the symposium. However, in addition to the symposium program, I enjoyed the cruise itself that had more than 10 water locks to go up to Perm and many events inside and outside the ship. Of course we enjoyed dinner and show time in the ship. But some cities along Volga River where we got off the ship and went sight-seeing were so impressive. For example, Saratov: a big heavy industry city which was famous for the extremely long bridge; Samara: where Yuri Alekseyevich Gagarin used to live after space, we visited Stalin’s Bunker 36 meters depth under the square; and Ulyanovsk: we visited a house where Vladimir Lenin was born. Finally in Perm we visited the office of the Academician of Russian Academy of Medical Sciences, Dr. Chereshnev. Then I went back to Moscow by airplane to go home to Japan. Dr. Korobov, who was working in Dr. Chereshnev's lab kindly took care of me from Perm to Sheremetyevo International Airport, Moscow. Ekaterinburug. Dr. Korneva invited me to attend the Congresses held in St. Petersburg in 2002 and 2003. In 2004, Dr. Korneva recommended me to participate in a big congress of Physiological Society XIX held in Ekaterinburg. I was so excited because I was asked to give a short speech in front of more than 1,000 audiences as a guest from Japan. In addition, I had an interview from the Press including TV cameras. In this Congress I presented a paper on brain mechanisms of an immunologically induced fatigue [8] and was asked many questions. Those questions encouraged me to do further experiments [9]. Recently we reported an involvement of neuroinflammation in this model of chronic fatigue syndrome [2]. In Ekaterinburg I visited the Church on Blood in Honor of All Saints Resplendent in the Russian Land, where the family of the Last Romanov’s tsar, Nicholai II, were killed. Then I was so impressed when I visited the forest where they were finally found. From 2006 to 2013. In 2006 I met Dr. Korneva in Moscow to attend the 8th World Congress of the International Society for Adaptive Medicine. From 2007, the International Symposium: Interaction of the nervous and immune systems in health and disease started to be organized by Russian Academy of Medical Sciences and Max-Planck Institute every 2 years in St. Petersburg. Dr. Oomura and I attended this symposium together from Japan, although he could not attend in 2013 because of his knee joint problem. Every time we visited St. Petersburg Dr. Korneva kindly invited us to her home and we had a dinner at her home. Because of her splendid hospitality, we always spent a comfortable and relax time. In 2013 Dr. Korneva gave me a chance to give a plenary lecture in the 4th Symposium on the interaction of the nervous and immune systems in health and disease. I presented my recent work on unique glycerophospholi- 40 МЕДИЦИНСКИЙ АКАДЕМИЧЕСКИЙ ЖУРНАЛ, 2014 г., ТОМ 14, № 4 pids, plasmalogens, which had anti-inflammatory, anti-amyloidogenic and anti-apoptotic actions [1, 3]. Conclusion. During several occasions to visit St. Petersburg Dr. Korneva provided me chances of not only studying neuroimmunomodulation but also seeing famous places. Dr. Rybakina took me to Alexander Nevsky Monastery, where I could see tombs of worldwide famous artists such as P. I. Tchaikovsky and F. M. Dostoevsky. She also took me to Catherine Palace and Park in Pushkin city to see the Amber room. I sincerely hope that Dr. Rybakina will recover from illness and return back to her laboratory soon. Dr. L. Churilov, Department of Pathophysiology, Faculty of Medicine, St. Petersburg University, who was introduced by Dr. Korneva, also took me and Dr. Oomura to Kronstadt and the oldest city, Novgorod. In addition he took us to the places where we could not have seen without his guide; D.I. Mendeleyev’s laboratory in the University of St. Petersburg and a special plastina-tion specimen laboratory in Department of Anatomy, St. Petersburg Military Medical School. I sincerely congratulate Dr. Korneva’s 85th anniversary and thank her that I have made many friends in Russia. Dr. Oomura will become 90 years old next year and he is still studying physiology. I hope that Dr. Korneva will also continue her work and looking forward to meeting with her in 5 th International Symposium 2015 held in St. Petersburg.

Toshihiko Katafuchi

Kyushu University

Fukuoka M.D., Ph.D. Department of Integrative Physiology, Graduate School of Medical Sciences

  1. Hossain M. S., Ifuku M., Take S. et al. Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling // PLoS ONE - 2013.- e83508. doi: 10.1371/journal.pone.0083508
  2. Ifuku M., Izumi K., Ootubo S. et al. Induction of IL-1a by activated microglia is prerequisite for immunologically induced fatigue // Eur. J. Neurosci.- 2014.- doi: 10.1111/ejn.12668
  3. Ifuku M., Katafuchi T., Mawatari S. et al. Anti-inflammatory/anti-amyloidogenic effects of plasmalogens in lipopolysaccharide-induced neuroinflammation in adult mice // J. Neuroinflammation.- 2012.- doi: 10.1186/1742-2094-9-197
  4. Katafuchi T., Take S., Hori T. Roles of sympathetic nervous system in the suppression of cytotoxicity of natural killer cells in the rat // J. Physiol. (Lond.).- 1993.- Vol. 465.- P. 343-357.
  5. Katafuchi T., Ichijo T., Take S., Hori T. Hypothalamic modulation of splenic natural killer cell activity in rats // J. Physiol. (Lond.).- 1993.- Vol. 471.- P. 209-221.
  6. Katafuchi T., Ichijo T., Hori T. Sequential relationship between actions of CRF and PGE2 in the brain on splenic sympathetic nerve activity in rats // J. Auton. Nerv. Syst.- 1997.- Vol. 67.- P. 200-206.
  7. Katafuchi T., Takaki A., Take S. et al. Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats // Mol. Brain Res.- 2003.- Vol. 118.- P. 24-32.
  8. Katafuchi T., Kondo T., Yasaka K. et al. Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-a mRNA in rats: a model for immunologically induced fatigue // Neuroscience.- 2003.- Vol. 120.- P. 837-845.
  9. Katafuchi T., Kondo T., Take S., Yoshimura M. Enhanced expression of brain interferon-a and serotonin transporter in immunologically induced fatigue in rats // Eur. J. Neurosci.- 2005.- Vol. 22.- P. 2817-2826.


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