THE ANALYSIS OF SICKNESS RATE OF RATS IN DIFFERENT LIGHT REGIMES
- Authors: Bukalev AV1, Vinogradova IA1
-
Affiliations:
- Petrozavodsk State University
- Issue: Vol 12, No 1 (2012)
- Pages: 36-45
- Section: Articles
- Published: 15.03.2012
- URL: https://journals.eco-vector.com/MAJ/article/view/9875
- DOI: https://doi.org/10.17816/MAJ12136-45
- ID: 9875
Cite item
Abstract
The influence of different light regimes (constant light - LL; constant darkness - DD; standard light regime - LD 12 hours light 12 hours darkness; natural lightening of the North-West of Russia - NL) on the dynamics of life’s sickness rate, spontaneous oncogenesis and frequency of some kinds of non-tumor pathology revealed at the post-mortem examination of male and female rats was studied. It was found out that the keeping of animals in LL and NL conditions led to the increase of the number of infectious diseases, substantially faster development of spontaneous tumors and the increase of non-tumor diseases in comparison with the animals kept in LD (standard light) regime. Light deprivation (DD) led to substantial reduction of development of new growth (in 2.1 times), of non-tumor and infectious diseases in comparison with the similar parameters in standard light regime.
Keywords
Full Text
![Restricted Access](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
About the authors
A V Bukalev
Petrozavodsk State UniversityPetrozavodsk, Russia
I A Vinogradova
Petrozavodsk State University
Email: irinav@petrsu.ru
Petrozavodsk, Russia
References
- Анисимов В. Н. Молекулярные и физиологические механизмы старения: В 2 т.- 2-е изд., перераб. и доп.- СПб.: Наука, 2008.-Т. 1.- 481 с.
- Заморский И. И., Пишак В. П. Функциональная организация фотопериодической системы головного мозга // Успехи физиол. наук.- 2003.- Т. 34, № 4.- С. 37-53.
- Pauley S. M. Lighting for the human circadian clock: recent research indicates that lighting has become a public health issue // Medical Hypotheses.- 2004.- Vol. 63.- P. 588-596.
- Raitier M. N. Proposed role of septohippocampal and pallidohabenuloraphe systems in photoperiodic time measurement // Med. Hypotheses.-1992.- Vol. 38.- P. 229-235.
- Виноградова И. А. Влияние различных световых режимов на показатели биологического возраста и развитие возрастной патологии у крыс // Мед. акад. журн.- 2005.- № 2, Прилож. 6.- С. 16-18.
- Cart J. J., Krewski D., Lee P. N., Torone R. E., Wahrendorf J. Statistical methods in cancer research // 1ARC Sci. Publ.- № 79.- Lyon: 1ARC, 1986.
- Turusov V. S., Mohr U. Pathology of tumours in laboratory animals.- Vol. 1. Tumours of the rat // 1ARC Sci. Publ.- № 99.- Lyon: 1ARC, 1990.
- Анисимов В. Н., Виноградова И. А. Световой режим, мелатонин и риск рака // Вопр. онкол.- 2006.- Т. 52, № 5.- С. 491-498.
- Анисимов В. Н., Виноградова И. А. Старение женской репродуктивной системы и мелатонин.- СПб.: Система, 2008.- 44 с.
- Комаров Ф. И., Рапопорт С. И., Малиновская Н. К., Анисимов В. Н. Мелатонин в норме и патологии.- М.: ИД Медпрактика-М, 2004.- 308 с.
- Cos S., Mediavilla D., Martinez-Campa C. et al. Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinomas in ruts // Сancer Lett.- 2006.- Vol. 235.- P. 266-271.
- Hansen J. Risk of breast cancer after night- and shift work: current evidence and ongoing studies in Denmark // Cancer Causes Control.- 2006.- Vol. 17.- P. 531-537.
- Van den Heilignerberg S., Depres-Brummer P., Barbason H. et al. The tumor promoting effect of constant light exposure on diethylnitrosamine-induced hepatocarcinogenesis in rats // Life Sci.- 1999.- Vol. 64.- P. 2523-2534.
- Fu L., Lee C.C. The circadian clock: pacemaker and tumor suppressor // Nature Rev. Caner.- 2003.- Vol. 3.- P. 350-361.
- Виноградова И. А., Букалев А. В., Забежинский М. А. и др. Влияние светового режима на развитие спонтанных опухолей у самок крыс // Вопр. онкол.- 2007.- Т. 53, № 5.- С. 554-561.
- Виноградова И. А., Букалев А. В., Забежинский М. А. и др. Влияние светового режима и мелатонина на гомеостаз, продолжительность жизни и развитие спонтанных опухолей у самцов крыс // Вопр. онкол.- 2008.- Т. 54, № 1.- С. 70-77.
- Vinogradova I. A., Anismov V. N., Bukalev A. V. et al. Circadian disruption induced by light-at-night accelerates ages and promotes tumorogenesis in rats // Aging.- 2009.- Vol. 1, № 10.- P. 1-11.
- Anisimov V. N., Baturin D. A., Popovich I. G. et al. Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice // Int. J. Cancer.- 2004.- Vol. 111.- P. 475-479.
- Baturin D. A., Alimova I. N., Anisimov V. N. et al. Effect of light regime and melatonin on the development of spontaneous mammary tumors in HER-2/neu transgenic mice is related to a downregulation of HER-2/neu gene expression // Neuroendocrinol. Lett.- 2001.- Vol. 22.-P. 439-445.
- Schernhammer E. S., Laden F., Speizer F. E. et al. Rotating night shifts and risk of breast cancer in women participating in the nurses’ health study // J. Natl. Cancer Inst.- 2001.- Vol. 93.- P.1563-1568.
- Anisimov V. N., Hansen J. Light, endocrine systems and cancer - a meeting report // Neuroendocrinology Lett.- 2002.- Vol. 23, suppl. 2.- P. 78-81.
Supplementary files
![](/img/style/loading.gif)