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COMPARATIVE STUDY OF HUMAN STEROID-PRODUCING SUB-CELLULAR FRACTIONS IMMUNE REACTIVITY IN AUTOIMMUNE FAILURE
- Authors: Khokhlov PP1, Sapronov NS1, Shabanov PD1
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Affiliations:
- Institute of Experimental Medicine NWB RAMS
- Issue: Vol 12, No 1 (2012)
- Pages: 59-65
- Section: Articles
- URL: https://journals.eco-vector.com/MAJ/article/view/9878
- DOI: https://doi.org/10.17816/MAJ12159-65
- ID: 9878
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Abstract
The purpose of the study was to identify and determine the immune reactivity of sub-cellular fractions of sreroidogenic cells and to measure quantitatively the organ specific autoantibodies. The high immunogenicity of microsomal fractions of human adrenal and gonad steroid-producing cells was shown as a result of investigation. The border levels for natural organ specific autoantibodies out of pathologies were established. In laboratory materials, the statistically significant increase of plasma antibodies to adrenocortical, ovarian and testicular antigens in immune mediated destruction of adrenals and gonads in humans was shown. The results are in good accordance with data of high immune reactivity of steroid genesis hydrolase enzymes. Their pathogenic role is more significant than the same of steroid hormones in states of immune pathology of the adrenal glands and gonads.
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About the authors
P P Khokhlov
Institute of Experimental Medicine NWB RAMSSt.-Petersburg, Russia
N S Sapronov
Institute of Experimental Medicine NWB RAMS
Email: sns@iemrams.spb.ru
St.-Petersburg, Russia
P D Shabanov
Institute of Experimental Medicine NWB RAMSSt.-Petersburg, Russia
References
- Michels A. W., Eisenbarth G. S. Immunologic endocrine disorders // J. Allergy Clin. Immunol.- 2010.- Vol. 125, Suppl. 2.- P. 226-237.
- Husebye E. S., Anderson M. S. Autoimmune polyendocrine syndromes: clues to 1diabetes pathogenesis // Immunity.- 2010.- Vol. 32, № 4.- P. 479-487.
- Bakalov V. K., Anasti J. N., Calis K. A. et al. Autoimmune oophoritis as a mechanism of follicular dysfunction in women with 46,XX spontaneous premature ovarian failure // Fertil. Steril.- 2005.- Vol. 84, № 4.- P. 958-965.
- Beck-Peccoz P., Persani L. Premature ovarian failure // Orphanet J. Rare Diseases.- 2006.- P. 1-9.
- Khole V. Does ovarian autoimmunity play a role in the pathophysiology of premature ovarian insufficiency? // J. Midlife Health.- 2010.- Vol. 1, №1.- P. 9-13.
- Потин В. В., Гзгзян А. М., Иоселиани Т. Г., Хохлов П. П. Иммунохимический метод количественного определения антител к антигенам стероид-продуцирующих клеток в сыворотке крови / Под ред. Э. К. Айламазяна.- СПб.: Изд-во Н-Л, 2007.- 28 с.
- Потин В. В., Гзгзян А. М., Хохлов П. П., Ворохобина Н. В. Способ количественного определения концентрации антител, специфичных к антигенам стероид-продуцирующих клеток человека, в биологических жидкостях человека, содержащих специфичные антитела.- Патент РФ № 2216742 от 11.01.2002.
- Triolo T. M., Baschal E. E., Armstrong T. K. et al. Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes // J. Clin. Endocrinol. Metab.- 2009.- Vol. 94, № 11.- P. 4527-4523.
- Pires E. S. Multiplicity of molecular and cellular targets in human ovarian autoimmunity: an update // J. Assist. Reprod. Genet.- 2010.-Vol. 27.- P. 519-524.
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).