OVARIAN AROMATASE P450 IN POLYCYSTIC OVARY SYNDROME
- Authors: Savina VA1, Kvetnoy IM1, Kleshchev MA1, Poteen VV1, Rulev VV1, Tarasova MA1, Tkachenko NN1, Jarmolinskaya MI1
-
Affiliations:
- Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical Sciences
- Issue: Vol 12, No 1 (2012)
- Pages: 66-72
- Section: Articles
- Published: 15.03.2012
- URL: https://journals.eco-vector.com/MAJ/article/view/9879
- DOI: https://doi.org/10.17816/MAJ12166-72
- ID: 9879
Cite item
Abstract
Full Text
About the authors
V A Savina
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical Sciences
Email: vasavina@mail.ru
St.-Petersburg, Russia
I M Kvetnoy
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
M A Kleshchev
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
V V Poteen
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
V V Rulev
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
M A Tarasova
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
N N Tkachenko
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
M I Jarmolinskaya
Ott’s Institute of Obstetrics and Gynecology Russian Academy of Medical SciencesSt.-Petersburg, Russia
References
- Knochenhauer E. S., Key T. J., Kahsar-Miller M. et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study // J. Clin. Endocrinol. Metab.- 1998.- Vol. 83, № 9.- P. 3078-3082.
- Michelmore K. F., Balen A. H., Dunger D. B. et al. Polycystic ovaries and associated clinical and biochemical features in young women // Clin. Endocrinol. (Oxf).- 1999.- Vol. 51, № 6.- P.779-786.
- Гинекология от пубертата до постменопаузы: практическое руководство для врачей / Э. К. Айламазян и др.- 2-е изд.- М.: МЕДпресс-информ, 2006.- C. 147-152.
- Назаренко Т. А., Дмитриев Д. В. Ингибиторы ароматазы в репродуктивной медицине // Проблемы репродукции.- 2007.- № 1.-С. 14-20.
- Simpson E. R. Biology of aromatase in the mammary gland // J. Mammary Gland Biol. Neoplasia.- 2000.- Vol. 5, № 3.- P. 251-258.
- Toda K., Simpson E. R., Mendelson C. R. et al. Expression of the gene encoding aromatase cytochrome P450 (CYP19) in fetal tissues // Mol. Endocrinol.- 1994.- Vol. 8, № 2.- P. 210-217.
- Вихляева Е. М. Синдром поликистозных яичников // Акуш. и гин.- 1973.- № 3.- C. 54-58.
- Erickson G. F., Hsueh A. J., Quigley M. E. et al. Functional studies of aromatase activity in human granulosa cells from normal and polycystic ovaries // J. Clin. Endocrinol. Metab.- 1979.- Vol. 49, № 4.- P. 514-519.
- Short R. V., London D. R. Defective Biosynthesis of Ovarian Steroids in the Stein-Leventhal Syndrome // Br. Med. J.- 1961.- Vol. 17, № 1.- P. 1724-1727.
- Deladoey J., Fluck C., Bex M. et al. Aromatase deficiency caused by a novel P450arom gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy // J. Clin. Endocrinol. Metab.- 1999.- Vol. 84, № 11.- P. 4050-4054.
- Harada N., Ogawa H., Shozu M. et al. Biochemical and molecular genetic analyses on placental aromatase (P450arom) deficiency // J. Biol. Chem.- 1992.- Vol. 267, № 7.- P. 4781-4785.
- Ludwig M., Beck A., Wickert L. et al. Female pseudohermaphroditism associated with a novel homozygous G-to-A (V370-to-M) substitution in the P-450 aromatase gene // J. Pediatr. Endocrinol. Metab.- 1998.- Vol. 11, № 5.- P. 657-664.
- Portrat-Doyen S., Forest M. G., Nicolino M. et al. Female pseudohermaphroditism (FHP) resulting from aromatase (P450arom) deficiency associated with a novel mutation (R457) in the CYP19 gene // Horm. Res.- 1996.- Vol. 46.- P. 14-20.
- Shozu M., Akasofu K., Harada T. et al. A new cause of female pseudohermaphroditism: placental aromatase deficiency // J. Clin. Endocrinol. Metab.- 1991.- Vol. 72, № 3.- P. 560-566.
- Gougeon A. Regulation of Ovarian Follicular Development in Primates: Facts and Hypotheses // End. Rew.- 1996.- Vol. 17, № 2.-P. 121-155.
- McNatty K. P., Hunter W. M., MacNeilly A. S. et al. Changes in the concentration of pituitary and steroid hormones in the follicular fluid of human graafian follicles throughout the menstrual cycle // J. Endocrinol.- 1975.- Vol. 64, № 3.- P. 555-571.
- Suzuki T., Sasano H., Sasaki H. et al. Quantitation of P450 aromatase immunoreactivity in human ovary during the menstrual cycle: relationship between the enzyme activity and immunointensity // J. Histochem. Cytochem.- 1994.- Vol. 42, № 12.- P. 1565-1573.
- Pigny P., Merlen E., Robert Y. et al. Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest // Clin. Endocrinol. Metab.- 2003.- Vol. 88, № 12.- P. 5957-5962.
- Морчиладзе А. З., Савина В. А., Ткаченко Н. Н. и др. Применение ингибитора ароматазы летрозола для индукции овуляции у женщин с синдромом поликистозных яичников // Журнал акушерства и женских болезней.- 2011.- Т. LX, вып. 2.- С. 52-58.
- Бебия З. Н., Орлов В. М. Возможная роль гиперпродукции яичниками антимюллеровского фактора в патогенезе хронической ановуляции при синдроме поликистозных яичников // Проблемы репродукции.- 2000.- № 6.- С. 12-15.
- Pellatt L., Rice S., Mason H. D. Anti-Mullerian hormone and polycystic ovary syndrome: a mountain too high? // Reproduction.- 2010.-Vol. 139, №5.- P. 825-833.
- Pellatt L., Rice S., Dilaver N. et al. Anti-Mullerian hormone reduces follicle sensitivity to follicle-stimulating hormone in human granulosa cells // Fertil. Steril.- 2011.- Vol. 96, № 5.- P. 1246-1251.
- Pache T. D., Wladimiroff J. W., de Jong F. H. et al. Growth Patterns of Nondominant Ovarian Follicles during the Normal Menstrual Cycle // Fertil. Steril.- 1990.- Vol. 54, № 4.- P. 638-642.