DELAYED COGNITIVE DEFICIT AS A RESULT OF NEONATAL LIPOPOLYSACCHARIDE EXPOSURE: A PRESUMABLE IMPLICATION OF LONG-LASTING CHANGES OF NEUROPLASTIC GENE EXPRESSION

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  • Authors: Trofimov AN1, Zubareva OE1,2, Schwarz AP3, Veniaminova EA1,4, Fomalont K1, Klimenko VM1
  • Affiliations:
    1. Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg
    2. Laboratory of Molecular Mechanisms of Neuronal Interactions, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
    3. Multidisciplinary Laboratory of Neurobiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg
    4. Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow
  • Issue: Vol 19, No 1S (2019)
  • Pages: 119-120
  • Section: Articles
  • Published: 15.12.2019
  • URL: https://journals.eco-vector.com/MAJ/article/view/19357
  • ID: 19357

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Abstract

Disorders of the CNS development at an early age caused by various types of perinatal pathology, such as infectious diseases, trauma, hypoxia and ischemia, often lead to the development of cognitive brain dysfunctions in adulthood. Proinflammatory cytokines play key role in these pathological processes and can affect the expression of genes involved in the regulation of neuroplasticity. This article describes the changes in the expression of fibroblast growth factor-2 (Fgf2), as well as genes encoding matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), proteins that by intercellular matrix re-modeling are involved in the regulation of neuroplasticity.

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About the authors

A N Trofimov

Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg

O E Zubareva

Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg; Laboratory of Molecular Mechanisms of Neuronal Interactions, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg

A P Schwarz

Multidisciplinary Laboratory of Neurobiology, I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, Saint Petersburg

E A Veniaminova

Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg; Laboratory of Psychiatric Neurobiology, Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow

K Fomalont

Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg

V M Klimenko

Laboratory of Neurobiology of the Brain Integrative Functions, I.P. Pavlov Department of Physiology, Institute of Experimental Medicine, Saint Petersburg

References

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  7. Veniaminova EA, Zubareva OE. The changes in exploratory behavior and Fgf2 gene expression in cells of the rat brain after the early postnatal administration of bacterial lipopolysaccharide. Neurochemical Journal. 2015;9(2):127-132.

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Copyright (c) 2019 Trofimov A.N., Zubareva O.E., Schwarz A.P., Veniaminova E.A., Fomalont K., Klimenko V.M.

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