Glutamate decarboxylase and its isoforms



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Abstract

The review summarizes current data on the properties, localization and physiological role of GABA synthesizing enzyme, glutamic acid decarboxylase, in mammalian tissues. Due to the high prevalence of the enzyme in the body’s cells and tissues, at the moment there is a large array of scattered experimental data, which needs to be processed and systematized. Presented data demonstrate the involvement of glutamate decarboxylase in different biochemical and physiological processes of the body. It has been demonstrated that the role of enzyme as the major component of the GABAergic neurotransmission in the central nervous system is the most intensively studied. However, there is only limited information regarding distribution and functional role of glutamate decarboxylase in the peripheral nervous system, and therefore requires additional research.

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About the authors

Valeria A. Razenkova

Institute of Experimental Medicine of the North-West Branch of the Russian Academy of Medical Sciences

Author for correspondence.
Email: valeriya.raz@yandex.ru
ORCID iD: 0000-0002-3997-2232
SPIN-code: 8877-8902
Scopus Author ID: 57219609984
ResearcherId: AAH-1333-2021

младший научный сотрудник отдела Общей и частной морфологии

Russian Federation

Dmitrii E. Korzhevskii

Institute of Experimental Medicine

Email: DEK2@yandex.ru
ORCID iD: 0000-0002-2456-8165
SPIN-code: 3252-3029
Scopus Author ID: 12770589000
ResearcherId: C-2206-2012

MD, Dr. Sci. (Med.), Professor of the Russian Academy of Sciences, Head of the Laboratory of Functional Morphology of the Central and Peripheral Nervous System, Department of General and Special Morphology

Russian Federation, Saint Petersburg

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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