Contemporary views at pathogenesis of the atherosclerosis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The article is devoted to accountof current ideas on pathogenesis of the atherosclerosis from the position of immune inflammation. Studies of last years showed that inflammation plays the key role in pathogenesis of the atherosclerosis. Immune cells dominate during initial atherosclerotic damages of arterial walls. Their effector molecules trigger atherosclerosis progress. Such approach to assessment of pathogenesis of the atherosclerosis allows searching for novel ways for prevention and suppression of immune inflammation progress. Nowadays vaccination and suppression of immune inflammation progress. Nowadays vaccination against main autoantigens is being successfully used. Modulation of immune response, which is including itself into the atherosclerosis, uses vaccination that induces immune protective response or development of tolerance via switch the process from Th1 to Th2 cellular response.

About the authors

V. A. Nagornev

Research Institute of Experimental Medicine of the RAMS

Author for correspondence.
Email: shabanov@mail.rcom.ru

академик РАМН

Russian Federation, Saint Petersburg

References

  1. Восканьянц А. Н, Нагорнев В. А. Пролиферация клеток стенки артерий при атерогенезе как фактор проявления иммунного воспаления // Цитокины и воспаление. 2004. Т. 3. № 4. С. 15-19.
  2. Денисенко А. Д., Виноградов А. Г., Нагорнев В. А. и др. Взаимодействие макрофагов с аутоиммунным комплексом липопротеид-антитело // Иммунол. 1989. № 2. С. 32-35.
  3. Иммунореактивность и атеросклероз / Под ред. А. Н. Климова. Л.: Медицина, 1986.
  4. Иоффе В. И, Зубжицкий Ю. Н, Нагорнев В. А., Климов А. Н. Иммунологическое исследование экспериментального атеросклероза // Бюл. экспер. биол. 1973. № 6. С. 72-76.
  5. Климов А. Н. Аутоиммунная теория атероге- неза и концепция модифицированных липопротеидов // Вести. АМН СССР. 1990. № 11. С. 30-36.
  6. Климов А. Н., Нагорнев В. А. Методические аспекты этиологии и патогенеза атеросклероза // Кардиол. 1993. № 3. С. 5-10.
  7. Нагорнев В. А., Восканъянц А. Н Атерогенез как иммуновоспалительный процесс // Вести. РАМН. 2004. № 7. С. 3-11.
  8. Нагорнев В. А., Мальцева С. В. Аутоиммунные и воспалительные механизмы развития атеросклероза // Арх. пат. 2005. № 5. С. 6-15.
  9. Нагорнев В. А., Анестиади В. X., Зота Е. Г. Атерогенез и иммунное воспаление. Кишинев, 1997.
  10. Нагорнев В. А., Анестиади В. X, Зота Е. Г. Атерогенез. Кишинев-СПб., 2001.
  11. И. Binder С. J., Hartvigsen К., Chang М. К. et al. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis // J. Clin. Invest. 2004. Vol. 114. P. 427-437.
  12. Brown M. A vaccine against atherosclerosis // D. D. T. 2002. Vol. 7. № 11. P. 588-590.
  13. Callaghan M. M., Lovis R. M., Rammohan C. et al. Autocrine regulation of collagenase gene expression by TNF-alpha in U937 // J. Leukoc. Biol. 1996. Vol. 59. P. 125-132.
  14. Choi J., Enis D., Koh К P. et al. T lymphocyte- endothelial cell interactions // Annu. Rev. Immunol. 2004. Vol. 22. P. 683-709.
  15. Freigang S., Horkko S., Miller E. et al. Immunization of LDL receptor-deficient mice with homologous malondialdehyde-modified and native LDL reduces progression of atherosclerosis by mechanisms other than inductions high titers of antibodies to oxidative neoepitopes // Arterioscler. Thromb. Vase. Biol. 1998. Vol. 18. P. 1972-1982.
  16. Frostegard J. Autoimmunity, oxidized LDL and cardiovascular disease // Autoimmun. Rev. 2002. Vol. 1. P. 233-237.
  17. George S. J. Tissue inhibitors of metalloproteinases and metalloproteinases in atherosclerosis // Curr. Opin. Lipidol. 1998. Vol. 9. P. 413-423.
  18. George J., Shoenfeld Y, Afek A. et al. Enhanced fatty streak formation in C57BL/6J mice by immunization with heat shock protein-65 // Arterioscler. Thromb. Vase. Biol. 1999. Vol. 19. P. 505-510.
  19. Hansson G. К Vaccination against atherosclerosis, science of fiction? // Circulation. 2002. Vol. 106. P. 337-356.
  20. Hansson G. K. Inflammation, atherosclerosis, and coronary artery disease // N. Engl. J. Med. 2005. Vol. 352. P. 1685-1695.
  21. Harats D., Yacov N., Gilburn B. Oral tolerance with heat shock protein-65 attenuates Mycobacterium tuberculosis-indiced and high- fat-diet-driven atherosclerotic lesions // J. Am. Coll. Cardiol. 2002. Vol. 40. P. 1333-1338.
  22. Huang Y, Mironova M., and Lopes-Virella M. F. Oxidized LDL stimulates matrix metalloproteinase-1 expression in human vascular endothelial cells // Arterioscler. Thromb. Vase. Biol. 1999. Vol. 19. P. 2640-2647.
  23. Jonasson L., Holm J., Skalli O. et al. Regional accumulation of T cells macrophages, and smooth muscle cells in the human atherosclerotic plaque // Arteriosclerosis. 1986. Vol. 6. P. 131-138.
  24. Klimov A. N., Denisenko A. D., PopovA. V. et al. Lipoprotein-antibody immune complexes, their catabolism and role in foam cell formation // Atherosclerosis. 1985. Vol. 58. P. 1-5.
  25. Klimov A. N., Nagornev V. A., Denisenko A. D. Immunoreactivity and atherosclerosis // Soc. Med. Rev. A. Cardiol. 1987. Vol. 1. P. 337-356.
  26. Lee Е., Grodzinsky A. J., Libby Р. et al. Human vascular smooth muscle cell-monocyte interactions and metalloproteinase secretion in culture // Arterioscler. Thromb. Vase. Biol. 1995. Vol. 15. P. 2284-2289.
  27. Libby R, Hansson G. K. Involvement of the immune system in human atherogenesis: Current knowledge and unanswered questions // Lab. Invest. 1991. Vol. 64. P. 5-15.
  28. Maron R., Sukhova G., Faria A. M. et al. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aorta arch of low-density lipoprotein receptordeficient mice // Circulation. 2002. Vol. 106. P. 1708-1715.
  29. Nagornev V. A., Maltseva S. The phenotype of macrophages which are not transformed into foam cells in atherogenesis // Atherosclerosis. 1996. Vol. 121. P. 246-251.
  30. Navab M., Imes S. S., Hama G. R et al. Monocyte transmigration induced by modification of low density lipoprotein in cocultures of human aortic wall cells is due to induction of monocyte chemotactic protein 1 synthesis and is abolished by high density lipoprotein // J. Clin. Invest. 1991. Vol. 8 8. P. 2939-2946.
  31. Nilsson J., Hansson G. K., Shah R K. Immunomodulation of atherosclerosis. Implications for vaccine development // Arterioscler. Thromb. Vase. Biol. 2005. Vol. 25. P. 18-28.
  32. Palinski W, Witztum J. L. Immune responses to oxidative neoepitopes on LDL and phospholipids modulate the development of atherosclerosis // J. Intern. Med. 2000. Vol. 247. P. 371-3 80.
  33. Palinsky W., Miller E., Witztum J. L. Immunization of low density lipoprotein (LDL) receptor deficient rabbits with homologous malondialde- hyde-modified LDL and oxidized LDL on early atherosclerosis in hypercholesterolemic rabbits // Proc. Natl. Acad. Sci. USA. 1995. Vol. 92. P. 821-825.
  34. Parhami E, Fang Z. T., Fogelman A. M. Minimally modified low density lipoprotein-induced inflammatory responses in endothelial cells are mediated by cyclic adenosine monophosphate // J. Clin. Invest. 1993. Vol. 92. P. 471-478.
  35. Pober J. S. Immunobiology of human vascular endothelium // Immunol. Res. 1999. Vol. 19. P. 225-232.
  36. Rajavashisth T. B., Andalibi A., Territo M. C. et al. Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins // Nature. 1990. Vol. 344. P. 254-257.
  37. Shaw R X., Horkko S., Chang M. K. et al. Natural antibodies with the T15 idiotype may act in atherosclerosis, apoptotic clearance, and protective immunity // J. Clin. Invest. 2000. Vol. 105. P. 1731-1740.
  38. Stemme S., Holm J., Hansson G. К. T lymphocytes in human atherosclerotic plaques are nomery cells espressing CD45RO and integrin VLA-1 //Arterioscler. Thromb. Vase. Biol. 1992. Vol. 12. P. 206-211.
  39. Stemme S., Faber B., Holm J. et al. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein // Proc. Natl. Acad. Sci. USA. 1995. Vol. 92. P. 3 893-3 897.
  40. Wick G., Knoflach M., and Xu Q. Autoimmune and inflammatory mechanisms in atherosclerosis // Ann. Rev. Immunol. 2004. Vol. 22. P. 361^103.
  41. Xu Q.f Kliendienst R., Waitz W et al. Increased expression of heat shock protein 65 coincides with a population of infiltrating T lymphocytes in atherosclerotic lesions of rabbits specifically responding to heat shock protein 65 // J. Clin. Invest. 1993. Vol. 91. P. 2693-2702.
  42. Yla-herttuala S., Palinski W, Butler S. W et al. Rabbit and human atherosclerosis lesions contain IgG that recognizes epitopes of oxidized LDL // Arterioscler. Thromb. 1994. Vol. 14. P. 32-40.
  43. Zhou X, Stemme S.t Hansson G. K. Evidence for a local immune response in atherosclerosis CD4+ T cells infiltrate lesions of apolipoprotein-E deficient mice // Am. J. Pathol. 1996. Vol. 149. P. 359-366.
  44. Zhou X, Caligiuri G., Hams ten A. et al. LDL immunization induces T-cell-dependent antibody formation and protection against atherosclerosis // Arterioscler. Thromb. Vase. Biol. 2001. Vol. 21. P. 108-114.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2007 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.