Role of 5-HT1А receptors in the cognitive functions of the brain and hormonal status in the estrogenes deficit

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Abstract

The aim of the present study was an assessment of 5-HT1A receptors participation in the behavioral and hormonal responses in the adult intact and ovariectomized (OVX) female rats. For this purposethe influence of chronic administration of 5-HT1A receptors agonist - 8-OH-DPAT (0,05 mg/kg, s.c.) and 5-HT1A receptors antagonist - NAN-190 (0,1 mg/kg, i.p.), injected separately or in a combination with 17p-estradiol (0,5 mg on each animal), within 14 days on the behavioral and hormonal status of the adults intact and ovariectomized (OVX) female rats was investigated. The learning was investigated on the model of passive avoidance per­formance, behavior of animals was estimated in the «open field» test and in the elevated plus maze, levels of hormones (FSH, LH, progesterone, estradiol) were determined by immunoenzyme analysis. Thus, the results obtained testify the involving of serotonergic receptors 1A and 1B subtypes in the mechanisms of behavioral processes realization, and also the hormonal control in the OVX female rats.

About the authors

N. S. Sapronov

Research Institute of the Experimental Medicine for the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, Saint Petersburg

Yu. О. Fedotova

Research Institute of the Experimental Medicine for the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

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