Dehydroepiandrosterone influence on reflex-conditioned activity and monoaminergic status in the ovariectomized female rats of mature age

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Abstract

This work is devoted to the analysis of an influence of chronic administration of DGA (0,1 mg/kg and 0,7 mg/kg, i. m.)on the passive avoidance performance in the ovariectomized rats of mature age (18 months), as well as in biogenic amines levels and their turnover in the different brain structures. It was established that chronic administration of DGA during 7 days in the high dose (0,7 mg/kg) corrected impairment of reproduction of this reflex in the ovariectomized rats of mature age, normalizing turnover of monoamines in the brain.

About the authors

N. S. Sapronov

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, St. Petersburg, 197376

Yu. O. Fedotova

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376

A. A. Bairamov

Research Institute of Experimental Medicine of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197376

References

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