Diversity of the systemic inflammatory response syndrome in neonatal sepsis

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Abstract

The lab-clinical survey of 94 newborn infants of the first week of life was made. The «А» group consisted of newborns with the hypoergic variant of sepsis (17 prematurely born with the gestation over 32 weeks and 11 born at term). The «В» group consisted of newborns with the hyperergic variant of sepsis (16 prematurely born with the gestation over 32 weeks and 27 born at term). 23 newborns with acute pneumonia comprised the group of comparison. Following lab-tests were made: determination of the level of 12 acute phase proteins, circulating immune complexes, IgG, IgM, IgA; STG, TTG, T3, the analysis of leukocyte formulas, four leukocyte indexes of reactivity. On the basis of the obtained results, patterns of 2 lab-clinical variants of the systemic inflammatory response syndrome (SIRS) have been suggested. SIRS pattern in hypoergic variant of sepsis is a deficient state with the prevalence of proteases in the spectrum of mediators on the background of hypothyroidism of septic genesis. SIRS pattern in hyperergic variant of sepsis is a «cytokine storm» with preserved hormonal provision of protein-synthetic processes and immunity.

About the authors

N. Р. Shabalov

Pediatric Medical Academy

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

D. O. Ivanov

Pediatric Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

N. N. Shabalova

Pediatric Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

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