Comparative evaluation of the efficiency of local radiation therapy in the treatment of patients with rheumatoid arthritis

Conducted evaluation of efficiency of methods of local radiation therapy to which pertain radioactive synovectomy (RS), X-raytherapy (XRT) and method offered by authors - local gammatherapy (LGT). Studied the record a clinic-laboratory factors including immunological under the influence of treatment.

Explored 175 patients suffering rheumatoid arthritis and got local radiation therapy on the knee joints. In the dependence from the type of treatment formed three groups of sick, which were similar on an age, sex and main features of disease. In all groups dominated the women senior 45 years, with duration RA more than 5 years and Il stage on X-ray of disease and moderate degree of general activity. Results: RS exceed other type of local radiation therapy on efficiency, particularly in removed a period of observation. Given method renders anti-inflammatory and immunosuppressional action, as evidenced by the track record of clinical, as laboratory data. Use new method of local radiation action - LGT - allows to obtain positive results more then beside half sick with RA, here with analgetic effect of given type therapy is observed during the path of treatment (62,3%) and exceeded RS LGT beside anti-inflammatory possesses immunosuppressional action herewith noted relaible record of laboratory and immunological data. XRT vastly yields on efficiency to rest methods that connected with the low total dose of irradiation. XRT renders nonspecifical anti-inflammatory action, not infusing on immune inflammation. This is caused smaller and transitory effect of XRT.

Local radiation therapy allows to raise efficiency of drug treatment of RA. Herewith RS and LGT possess immunosuppressional action that ensures their high efficiency, then XRT is characterized by only short-lived antiinflammatory effect.