Genetic analysis of organism sensitivity to tuberculosis infection

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The genetic sensitivity of orgamism to tuberculosis infection is reviewed in the article with special accent immunnity processes. NK cells, macrophages, CD4, CD8, lymphocytes, I and 1b molecules, Tir-like receptors, oxigen active forms, chemokines, difensines and cytokines participate in formation of organism resistence to M. tuberculosis. In innate immunity, interferon-gamma plays a key role determining host sensitivity to tuberculosis infection. It is produced by NK cells and activates macrophagal cells. In adaptive immunity, CD4 and CD8 lymphocytes cells also produce interferon-gamma, which acts on macrophagal cells and supports Th1 differentiation. The subsequences of gene elimination in knock out mice are reviewed as well.

About the authors

S. A. Ketlinskii

State Institute of the High Pure Biopreparations

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

References

  1. Пигарева Н.В., Симбирцев А.С., Колобов А.А. и др. Изучение иммуномодулирующей активности нового пептидного соединения бестима // Иммунология. 2000. № 1. С. 33-35
  2. Altare F., Durandy A., Lammas D. et. al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency // Science. 1998. Vol. 280. P. 1432-1438.
  3. Adams L., Dinauer M., Morgenstern D., et al. Comparison of the roles or reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic mice // Tuber. Lung Dis. 1997. Vol. 78. № 5-6. P. 237-246.
  4. Bean A., Roach D., Briskoe H. et al. Structural deficiencies in granuloma formation in TNF genetargeted mice underline the heightened susceptibility to aerosole Micobacterium tuberculosis infection, which is not compensated for by lymphotoxin //J. Immunology. 1999. Vol. 162. P. 3504-3511.
  5. Bechar S., Dascher C., Grusby M. et al. Susceptibility of mice deficient in CDID or TAPI to infection with Mycobacterium tuberculosis // J. Exp. Med. 1999. Vol. 180. № 12. P. 1973-1980.
  6. Bermudez L., Goodman J., Petrofsky V. Role of complement receptors in uptake of Mycobacterium avius by macrophages in vivo: evidence from studies using CD18-deficient mice // Infection and Immunity. 1999. Vol. 67. № 9. P. 4912-4916.
  7. Bermudez L., Petrofsky M. Host defense against Mycobacteriumavium does not have an absolute requirement for Major Histocompatibility Complex class I-restricted T cells// Infection and Immunity. 1999. Vol. 67. № 6. P. 3108-3111.
  8. Beutler B. Tlr4: central component of the sole mammalian LPS sensor // Current Opinion in Immunology. 2000. Vol. 12. № 1. P. 20-26.
  9. Beutler B., Poltarak A. Positional cloning of LPS, and the general role of toll-like receptors in the innate immune response // Eur. Cytokine Netw. 2000. Vol. 11. № 2. P. 143-152.
  10. Bogdan C., Rollinghoff M., Diefenbach A. Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity// Current Opinion in Immunology. 2000. Vol. 12. P. 64-67.
  11. Bosio C., Gardner D., Elkins K. Infection of B-cell - deficient mice CDC 1551, a clinical isolate of Micobacteria tuberculosis: delay in dissemination and development of lung pathology // J. Immunol. 2000. Vol. 164. № 12. P. 6417-6425.
  12. Boussiotis V., Tsai E., Yunis E., et al. IL-10- producing T cells suppress immune responses in anergic tuberculosis patients // J. Clin. Invest. 2000. Vol. 105. № 9. P. 1317-1325
  13. Cho S., Mehra Y., Thoma-Uszynski S. et al. Antiimicrobial activity of MHC class I-restricted CD8+ T cells in human tuberculosis // Proc. Natl. Acad. Sci. USA. 2000. Vol. 97. № 22. P. 12210- 12215.
  14. Collins H., Schihle U., Kauffmann S. Early IL-4 induction in bonr marrow lymphoid precursor cells by mycobacterial lipoarabinomannan // J. Immunology. 1998. Vol. 161. № 9. P. 5546-5554.
  15. Cooper F., Dalton D., Stewart T. Disseminated tuberculosis in interferon gamma gene-disrupted mice // J. Exp. Med. 1993. Vol. 178. № 6. P. 2243-2247.
  16. Cooper A., Sousa C., Frank A. et al. The course of Mycobacterium tuberculosis infection in the lungs of mice lacking expression of either perforin-or granzyme-Mediated Cytolytic Mechanisms// Infection and Immunity. 1997. Vol. 65. № 4. P. 1317-1320.
  17. Dalton D., Haynes L., Chu C. et al. IFN-gamma eliminates responding CD4 T cells during micobacterial infection by inducing apoptosis of activated CD4 T cells. // J. Exp. Med. 2000. Vol. 192. № 1. P. 117-122.
  18. Dieli F., Singh M., Spallck R. et al. Change of Th0 to Thl cell-cytokine profile folowing tuberculosis chemotherapy // Scand. J. Immunol. 2000. Vol. 52. № 1. P. 96-102.
  19. Doherty T., Sher A. IL-12 promotes drug-induced clearence of Mycobacterium avium infection in mice// J. Immunol. 1998. Vol. 160. № 11. P. 5428-5435.
  20. Durandy A., Lammas D., Emile J. et al. Impairment of mycobacteriall immunity in human interleukin12 receptor deficiency // Science. 1998. Vol. 29. № 5368. P. 1432-1435.
  21. Ehlers S., Benini J., Kutsch S. Fatal granuloma necrosis without exacerbated mycobacterial growth in tumor necrosis factor receptor p55 genedeficient mice intravenously infected with Mycobacterium avium // Infection and Immunity. 1999. Vol. 67. № 7. P. 3571-3579.
  22. Ehlers S., Kutsch S., Ehlers E. et al. Lethal granuloma disintegration in mycobacteria-infected TNFRp55/ mice is dependent on tT cells and IL-12 // J. Immunol. 2000. Vol. 165. N 1. P. 483-1492.
  23. Ehlers S., Richter F. Gamma interferon is essential for clearing Mycobacterium genavense infection // Infect. Immune. 2000. Vol. 68. № 6. P. 3720—3723.
  24. Emoto M., Emoto Y.,Buchwalow I. et al. Induction of IFN-gamma-producing CD4+ natural killer T cells by Mycobacterium bovis bacillus Calmette Gueren// Eur. J. Immunol. 1999. Vol. 29. № 2. P. 650-659.
  25. Erb K., Holloway J., Sobeck A. et al. Infection of mice Mycobacterium bovis-Bacillus CalmetteGeren (BCG) supresses allergen-induced airway eosinophilia // J. Exp. Med. 1998. Vol. 187. № 4. P. 561-569
  26. Flynn J., Chan J., Triebold K. et al. An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection // J. Exp. Med. 1993. Vol. 178. № 6. P. 2249-2254.
  27. Flynn J., Ernst J. Immune responses in tuberculosis // Current Opinion in Immunology. 2000. Vol. 12. № 4. P. 432-436
  28. Garcia J., Guler R., Vesin D. et al. Lethal Mycobacterium bovis Bacillus Calmette Guerenn infection in nitric oxidee synthase 2-defficient mice: cell-mediated immunity requires nitric oxide synthase 2. // Lab. Invest. 2000. Vol. 80. № 9. P. 1385-1397.
  29. Gomes M., Florido V., Pais T. et al. Improved clearence of Mycobacterium avium upon disruption of the inducible nitric oxide synthase gene // J. Immunol. 1999. Vol. 162. № 1. P. 6734-6739.
  30. Grange J.The immunophisiology and immunopathology of tuberculosis // Clinical tuberculosis/Ed. by P.D.O. Davis. London: Chapment and Hall, 1994. P. 55-71.
  31. Hu C., Mayadas-Norton T., Tanaka K. et al. Mycobacterium tuberculosis infection in complement receptor 3-deficient mice // J. Immunol. 2000. Vol. 165. № 5. P. 2596 -2602.
  32. Jacobs M., Marino M., Brown N. et al. Correlation of defective host responce to Mycobacterium bovis BCG infection in TNF – defficient mice by bone marrow trasnsplantation // Lab. Invest. 2000. Vol. 80. № 6. P. 901-914.
  33. Johnson C., Cooper A., Frank A. et al. Adequate expression of protective immunity in the absence of granuloma formation in Mtb-infected mice with a disrution in the intracellular adhesion molecule 1 gene // Infect. Immun. 1998. Vol. 66. № 4. P. 1666-1670.
  34. Jong R., Altare F., Haagen I. et al. Severe micobacterial and salmonella infections in interleukin-12 receptor-deficient patients // Science. 1998. Vol. 280. P. 1435-1438.
  35. Juffermans N., Verbon A., Belisle J. et al. MycobacterialIIII lipoarabinomannan induces an inflammatory response in the mouse lung. A role for interleukin-1 // Am. J. Respir. Crit Care Med. 2000. Vol. 162. № 2. Pt 1. P. 486-489.
  36. Mac Micking J., North R., LaCourse R. et al. Identification of nitric oxide synthase as a protective locus against tuberculosis // Proc. Natl. Acad. Sci. USA. 1997. Vol. 94. P. 5243-5248.
  37. Manjunath N., Fratazzi C., Arbeit R. et al. A macrophage invasion mechanism for mycobacteria implicating the extracellular domain of CD43 // J. Exp. Med. 2000. Vol. 192. № 2. P. 183-192.
  38. Mannering S., Zhan V., Gelberston B. et al. T lymphocytes from granulocyte colony-stimulating factor-/- mice produce large quantities of interferon-gamma in a chronic infection model // Immunology. 2000. Vol. 101. № 1. P. 132–139.
  39. Means T., Wang S., Lien E. et al. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis // J. Immunol. 1999. Vol. 163. № 3. P. 3920-3927.
  40. Medzhitov R., Janeway C. Innate immunity: the virtues of nonclonal system recognition // Cell. 1997. Vol. 95. № 1. P. 205-212.
  41. Medzhitov R., Preston-Harlburt P., Janeway C. A human homologue of the drosofila Toll protein signals activation of adaptive immunity // Nature. 1997. Vol. 388. P. 394-396.
  42. Melo M., Catchpole I., Haggar G. et al. Utilization of CD11b knockout mice to characterize the role of complement receptor 3 (CR3, CD11b/CD18) in the grouth of mycobacterium tuberculosis in macrophages // Cell Immunol. 2000. Vol. 10. № 1. P. 13-23.
  43. Mims C., Dimmock N., Nash A. et al. Mims'Pathogenesis of Infection Disease. Academic Press. 1997. P. 1-414.
  44. Mohammed K., Nasreen N., Ward M. et al. Helper T-cell type 1 and 2 cytokines regulate C-C chemokine expression in mouse pleural mesothelial cells // Am. J. Respir. Crit. Care. Med. 1999. Vol. 159. P. 1953-1659
  45. Murray P., Young R. Increased antybacterial immunity in interleukin-10-deficient mice // Infection and Immunity. 1999. Vol. 67. № 6. P. 3087-3095.
  46. Rojas R., Balaji K., Subramanian A. et al. Regulation of human CD4+ ab T-cell receptor positive (TCR) and gd TCR+ T cell responses to Mtb by IL-10 and TGFb // Infection and Immunity. 1999. Vol. 67. № 12. P. 6461-6472.
  47. Russo D., Koslova N., Lakey D. et al. Naive human T cells develop into Th1 effectors after stimulation with mycobacterium tuberculosis-infected macrophages or recombinant Ag85 proteins // Infect. Immun. 2000. Vol. 68. № 12. P. 6826- 6832.
  48. Saunders B., Frank A., Orme I. et al. Interleukin-6 induces early gamma interferon production in the infected lung but is not required for generation of specific immunity to Mycobacterium tuberculosis infection // Infection and Immunity. 2000. Vol. 68. № 6. P. 3322-3326.
  49. Sauty A., Dziejman M., Taha R. et al. The T cellspecific CXC chemokines IP-10, Mig and I-TAC are expressed by activated human bronchial epithelial cells // J. Immunol. 1999. Vol. 162. № 4. P. 3549-3558.
  50. Schaible U., Kaufman S. CD1 and CD1-restricted T-cells in infections with intracellular bacteria // Trends in Microbiology. 2000. Vol. 8. P. 419- 425.
  51. Souza C., Cooper A., Frank A. et al. A novel nonclassic beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung // Am. J. Respir. Cell Mol. Biol. 2000. Vol. 23. № 2. P. 188-193.
  52. Souza S., Denis O., Scorza T. et al. CD4+ T cells contain Mycobacterium tuberculosis infection in the absence of CD8+ T cells in mice vaccinated with DNA encoding Ag 85A // Eur. J. Immunol. 2000. Vol. 30. № 9. P. 2455-2459.
  53. Sousa A., Mazzacaro R., Russell R. et al. Relative contribuyions of distinct MHC class I dependent cell populations in proitection to tuberculosis infection in mice // Proc. Natl. Acad. Sci. USA. 2000. Vol. 97. № 8. P. 4204-4208.
  54. Sugavara I., Yamada H., Kaneco H. et al. Role of interleukin-18 (IL-18) in mycobacterial infection in IL-18-gene-disrupted mice // Infect. Immun. 1999. Vol. 67. № 5. P. 2585-2589.
  55. Szalay G., Zugel U., Ladel C. et al. Participation of group 2 CDI moleculesin the control of murine tuberculosis // Microbes Infect. 1999. Vol. 14. P. 1153-1157.
  56. Takeuchio O., Hoshino K., Kawal T. Different roles of Tlr2 and Tlr4 in recognition of Gram-negative and Gram-positive bacterial cell wall components // Immunity. 1999. Vol. 11. P. 435-451.
  57. Tascon R., Stavropoulos E., Lucacs R. et al. Protection against Mycobacterium yuberculosis infection by CD8+ T cells reqauires the production of gamma interferon // Infect. Immun. 1998. Vol. 66. № 2. P. 830-834.
  58. Underhill D., Ozinsky A., Smith K. et al. Toll-like receptor - 2 mediates mycobacteria-induced proinflammatory signalling in macrophages // Proc. Natl. Acad. Sci. USA. 1999. Vol. 96. № 25. P. 14459-14463.
  59. Wakeham J., Wang J., Magram J. et al. Lack of both types 1 and 2 cytokines, tissue inflammatory responses and immune protection during pulmonary ifection by Micobacteria bovis Bacille Calmett-Guerin in IL-12-deficient mice // J. Immunology. 1998. Vol. 160. № 11. P. 6101- 6111.
  60. Yamada H., Mizumo S., Horai R. Protective role of IL-1 in micobacterial infection in IL-1 alpha/beta double-knockout mice // Lab. Invest. 2000. Vol. 80. № 5. P. 759-767.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2001 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.