Email this article Cytogenetic findings in patients with chronic lymphocytic leukemia
- Authors: Koljubaeva S.N.1, Sargevsky V.О.1, Titova A.A.1, Krasnova О.R.1, Viktorova N.A.1
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Affiliations:
- Military Medical Academy
- Issue: Vol 6, No 3 (2006)
- Pages: 109-114
- Section: Clinical medicine
- Published: 25.08.2006
- URL: https://journals.eco-vector.com/MAJ/article/view/693564
- ID: 693564
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Abstract
Cytogenetic indexes in bone marrow and peripheral blood cells of 26 patients with CLL were explored. No changes in bone marrow cells were detected. In peripheral blood clonal changes were find in 17 pathients (65%), including trisomy 12 (18,5% from total number patients), rearrangements in chromosome 14 (7,7%), different abnormalities in 4q (18,5%). Clone with additional X-chromosome was detected in 18,5% of patients which may be considered as main or as additional clone in CLL.
The number of clonal cells differes from 2% to 75% depending on the form and stage of the desease. PHA and IL were equally efficient in cells stimulation. Obviously the frequency of chromosomal abnormalities depends on the quantity of analysed cells.
About the authors
S. N. Koljubaeva
Military Medical Academy
Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
V. О. Sargevsky
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
A. A. Titova
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
О. R. Krasnova
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
N. A. Viktorova
Military Medical Academy
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg
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Supplementary files
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).