Participation of D1- and D2-dopaminergic receptors in modulation of the behavioral processes in estrogenes imbalance

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Abstract

The aim of the present study was an assessment of Dr and D2-dopaminergic receptors participation in modulation of the behavioral responses in the adult intact during ovary cycle and ovariectomized (OVX) female rats. For this purpose the influence of chronic administration of D^dopaminergic receptors antago­nist - SCH-23390 (0,1 mg/kg) and D2-dopaminergic receptors antagonist - sulpiride (10,0 mg/kg), injected separately or in a combination with 17p-estradiol (0,5 mg on each animal), within 14 days on the behavioral status of the adults intact and ovariectomized (OVX) female rats was investigated. The learning was investi­gated on the model of passive avoidance performance, behavior of animals was estimated in the «open field» test. It was established that chronic administration of SCH-23390 or sulpiride improved formation of passive avoidance performance in all phases of ovary cycle. SCH-23390 administration alone or in combination with 17p-estradiol completely restored passive avoidance performance in OVX rats. Thus, the results obtained suggest the different role of D1- and D2-dopaminergic receptors in the mechanisms of behavioral processes realization in the intact and OVX female rats.

About the authors

Y. О. Fedotova

The Scientific Research Institute of the Experimental Medicine for the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

Е. I. Malygina

The Scientific Research Institute of the Experimental Medicine for the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

N. S. Sapronov

The Scientific Research Institute of the Experimental Medicine for the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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