Behavioral effects of corticoliberin administered into the brain ventriculi of rats

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Abstract

The behavioral effects of native human corticotropin-releasing hormone (CRH) and its agonists D-Glu-20 (Rj) and D-Pro-5 (R2) administered into the lateral brain ventriculus (0.01-1 mkg) of Sprague-Dowley rats in open field, dark-light, Y-maze and place preference tests. The different action of CRH and its agonists on anx­iety level and short-term memory was revealed. D-Glu-20, a R1 agonist of CRH, acted as an anxiogen in open field and dark-light tests. D-Pro-5, a R2 agonist of CRH, did not cause a typical anxiogenic effect, but did non­specific suppression of behavior. D-Pro-5 only in high doses decreased a number of entries into the light box in dark-light test. At the same time, that compound both enhanced the short-term memory in maximal degree and prevented the memory decrease induced by diazepam. The data obtained are in agree with the findings of literature about differential participation of R, and R? receptor systems of CRH in regulation of emotional and mnemic components of behavior. The anxiogenic action of CRH is connected with activation of R1 recep­tors of CRH.

About the authors

Р. D. Shabanov

Military Medical Academy

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

A. A. Lebedev

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

V. V. Rusanovsky

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

V. F. Streltsov

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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