Analysis of the cytomegalovirus infection in prostate of patients with prostate cancer and benign hyperplasia of prostate

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Abstract

Prostate tissue is а habitat for multiple viral infections with oncogenic or oncomodulating capacity, but the importance of that fact for the development of such complicated process as oncogenesis in prostate is unknown. Cytomegolovirus is one of such viruses. We studied by the PCR and RT PCR the presence of the DNA and mRNA of HCMV in tissue samples and leucocytes of patients with prostate cancer and benign hyperplasia of prostate. ln addition we measured а level of lgG antibodies to HCMV in plasma of this patients. We demonstrated high rate of HCMV infection in tissue samples with expression of vlL10 gene of HCMV in some cases, low rate of HCMV infection in leucocytes and high level of HCMV lgG in plasma of patients.

About the authors

Т. G. Кlochkova

Central Research lnstitute of Rontgenology and Radiology

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

Т. Т. Andabekov

Central Research lnstitute of Rontgenology and Radiology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

R. B. Samsonov

Central Research lnstitute of Rontgenology and Radiology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

M. I. Karelin

Central Research lnstitute of Rontgenology and Radiology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

M. I. Shkolnik

Central Research lnstitute of Rontgenology and Radiology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

A. V. Semenov

City Virological Consultative and Diagnostic Center, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

G. R. Vinogradskaia

В. Р. Konstantinov Petersburg Nuclear Physics lnstitute

Email: medaj@eco-vector.com
Russian Federation, Gatchina

V. I. Evtushenko

Central Research lnstitute of Rontgenology and Radiology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg

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Copyright (c) 2008 Кlochkova Т.G., Andabekov Т.Т., Samsonov R.B., Karelin M.I., Shkolnik M.I., Semenov A.V., Vinogradskaia G.R., Evtushenko V.I.


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