The effect of the composition of leuzea and cranberry meal extracts on testosterone level in mice
- Authors: Khalikova D.A.1, Ankov S.V.1, Meshkova J.V.1, Tolstikova T.G.1
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Affiliations:
- Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
- Issue: Vol 21, No 4 (2021)
- Pages: 67-72
- Section: Original research
- Published: 15.12.2021
- URL: https://journals.eco-vector.com/MAJ/article/view/90692
- DOI: https://doi.org/10.17816/MAJ90692
- ID: 90692
Cite item
Abstract
BACKGROUND: Current research suggests the potential use of natural components as sources of anabolic compounds. One of these is a new composition of leuzea and cranberry meal extracts, which, as was found earlier, exhibits a dose-dependent anabolic effect.
AIM: To establish the supposed mechanism of the anabolic effect in the composition of leuzea and cranberry meal extracts.
MATERIALS AND METHODS: In the experiment, CD-1 mice of both sexes weighing 20–25 g were used. All animals were measured blood testosterone concentration in dynamics: 0 point (before the administration of the analyzed compositions), 30, 60, 120, 180 minutes after administration.
RESULTS: After a single administration of the composition of leuzea and cranberry meal extracts at a dose of 70+500 mg/kg, the level of testosterone in the blood mice of both sexes increases, and the increase in testosterone levels in females is less pronounced than in males.
CONCLUSIONS: One of the supposed mechanisms of the anabolic effect in the composition, characterized by an increase in blood testosterone levels, has been established.
Keywords
Full Text
About the authors
Daria A. Khalikova
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: dasha.halikova@mail.ru
ORCID iD: 0000-0002-3932-2491
Postgraduate at the Laboratory of Pharmacological Research
Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090Sergey V. Ankov
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: sergey.ankov42@gmail.com
ORCID iD: 0000-0001-5588-8420
Cand. Sci. (Biol.), Research Associate of the Laboratory of Pharmacological Research
Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090Julia V. Meshkova
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Author for correspondence.
Email: meshkova_29@mail.ru
ORCID iD: 0000-0002-5935-2540
Junior Researcher of the Laboratory of Pharmacological Research
Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090Tatiana G. Tolstikova
Vorozhtzov Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Science
Email: tg_tolstikova@mail.ru
ORCID iD: 0000-0002-3750-2958
Dr. Sci. (Biol.), Professor, Head of the Laboratory of Pharmacological Research
Russian Federation, 9, Academician Lavrentiev Ave., Novosibirsk, 630090References
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